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Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer’s disease brain

BACKGROUND: Mitochondrial dysfunction is a feature of neurodegenerative diseases, including Alzheimer’s disease (AD). Changes in the mitochondrial DNA copy number (mtDNAcn) and increased mitochondrial DNA mutation burden have both been associated with neurodegenerative diseases and cognitive decline...

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Detalles Bibliográficos
Autores principales:	Klein, Hans-Ulrich, Trumpff, Caroline, Yang, Hyun-Sik, Lee, Annie J., Picard, Martin, Bennett, David A., De Jager, Philip L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572491/ https://www.ncbi.nlm.nih.gov/pubmed/34742335 http://dx.doi.org/10.1186/s13024-021-00495-8

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