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Retinal Microcirculatory Responses to Hyperoxia in Primary Open-Angle Glaucoma Using Optical Coherence Tomography Angiography
PURPOSE: To investigate the retinal vascular response to hyperoxia in patients with primary open-angle glaucoma (POAG) using optical coherence tomography angiography (OCTA). METHODS: This prospective study included 27 eyes in 27 patients with POAG and 14 eyes in 14 age- and sex-matched healthy parti...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572508/ https://www.ncbi.nlm.nih.gov/pubmed/34730793 http://dx.doi.org/10.1167/iovs.62.14.4 |
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author | Fan, Xintong Xu, Huan Zhai, Ruyi Sheng, Qilian Kong, Xiangmei |
author_facet | Fan, Xintong Xu, Huan Zhai, Ruyi Sheng, Qilian Kong, Xiangmei |
author_sort | Fan, Xintong |
collection | PubMed |
description | PURPOSE: To investigate the retinal vascular response to hyperoxia in patients with primary open-angle glaucoma (POAG) using optical coherence tomography angiography (OCTA). METHODS: This prospective study included 27 eyes in 27 patients with POAG and 14 eyes in 14 age- and sex-matched healthy participants. Retinal radial peripapillary capillary (RPC) perfusion was measured by OCTA before and after inhaling oxygen in all participants. Systemic hemodynamic variables were also examined and recorded before and after hyperoxia. RESULTS: Hyperoxia significantly reduced the perfused vessel density (PVD) of RPCs in both healthy controls (baseline and hyperoxia: 54.2 ± 4.1 and 51.0 ± 4.4, respectively, P < 0.001) and patients with POAG (baseline and hyperoxia: 44.7 ± 6.1 and 43.2 ± 5.4, respectively, P = 0.001). However, the changes in peripapillary PVD between the two gas conditions in patients with POAG were significantly lower than in healthy controls, including both the absolute change (baseline-hyperoxia: 1.5 ± 2.0 and 3.2 ± 1.2, respectively, P = 0.006) and relative change (ratio of absolute change and baseline value: 3.0% ± 4.6% and 6.0% ± 2.4%, respectively, P = 0.04). CONCLUSIONS: Retinal microvasculature responds to hyperoxia by reducing RPC perfusion in both healthy participants and patients with POAG. However, this vasoreactivity capacity was significantly impaired in patients with POAG. |
format | Online Article Text |
id | pubmed-8572508 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Association for Research in Vision and Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-85725082021-11-15 Retinal Microcirculatory Responses to Hyperoxia in Primary Open-Angle Glaucoma Using Optical Coherence Tomography Angiography Fan, Xintong Xu, Huan Zhai, Ruyi Sheng, Qilian Kong, Xiangmei Invest Ophthalmol Vis Sci Glaucoma PURPOSE: To investigate the retinal vascular response to hyperoxia in patients with primary open-angle glaucoma (POAG) using optical coherence tomography angiography (OCTA). METHODS: This prospective study included 27 eyes in 27 patients with POAG and 14 eyes in 14 age- and sex-matched healthy participants. Retinal radial peripapillary capillary (RPC) perfusion was measured by OCTA before and after inhaling oxygen in all participants. Systemic hemodynamic variables were also examined and recorded before and after hyperoxia. RESULTS: Hyperoxia significantly reduced the perfused vessel density (PVD) of RPCs in both healthy controls (baseline and hyperoxia: 54.2 ± 4.1 and 51.0 ± 4.4, respectively, P < 0.001) and patients with POAG (baseline and hyperoxia: 44.7 ± 6.1 and 43.2 ± 5.4, respectively, P = 0.001). However, the changes in peripapillary PVD between the two gas conditions in patients with POAG were significantly lower than in healthy controls, including both the absolute change (baseline-hyperoxia: 1.5 ± 2.0 and 3.2 ± 1.2, respectively, P = 0.006) and relative change (ratio of absolute change and baseline value: 3.0% ± 4.6% and 6.0% ± 2.4%, respectively, P = 0.04). CONCLUSIONS: Retinal microvasculature responds to hyperoxia by reducing RPC perfusion in both healthy participants and patients with POAG. However, this vasoreactivity capacity was significantly impaired in patients with POAG. The Association for Research in Vision and Ophthalmology 2021-11-03 /pmc/articles/PMC8572508/ /pubmed/34730793 http://dx.doi.org/10.1167/iovs.62.14.4 Text en Copyright 2021 The Authors https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License. |
spellingShingle | Glaucoma Fan, Xintong Xu, Huan Zhai, Ruyi Sheng, Qilian Kong, Xiangmei Retinal Microcirculatory Responses to Hyperoxia in Primary Open-Angle Glaucoma Using Optical Coherence Tomography Angiography |
title | Retinal Microcirculatory Responses to Hyperoxia in Primary Open-Angle Glaucoma Using Optical Coherence Tomography Angiography |
title_full | Retinal Microcirculatory Responses to Hyperoxia in Primary Open-Angle Glaucoma Using Optical Coherence Tomography Angiography |
title_fullStr | Retinal Microcirculatory Responses to Hyperoxia in Primary Open-Angle Glaucoma Using Optical Coherence Tomography Angiography |
title_full_unstemmed | Retinal Microcirculatory Responses to Hyperoxia in Primary Open-Angle Glaucoma Using Optical Coherence Tomography Angiography |
title_short | Retinal Microcirculatory Responses to Hyperoxia in Primary Open-Angle Glaucoma Using Optical Coherence Tomography Angiography |
title_sort | retinal microcirculatory responses to hyperoxia in primary open-angle glaucoma using optical coherence tomography angiography |
topic | Glaucoma |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572508/ https://www.ncbi.nlm.nih.gov/pubmed/34730793 http://dx.doi.org/10.1167/iovs.62.14.4 |
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