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THE IMPACT OF HEMATOLOGICAL PARAMETERS ON SURVIVAL FOR PATIENTS WITH COVID-19

OBJECTIVE: Coronavirus disease 2019 is an infectious disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clinical and laboratory predictors may identification of patients at risk of mortality and guide treatment .To analyze laboratory abnormalities in patients w...

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Autores principales: YILMAZ, Fatma, ALBAYRAK, Murat, YILDIZ, Abdülkerim, AFACAN ÖZTÜRK, Hacer Berna, MARAL, Senem, MALKAN, Ümit Yavuz, AKYOL, Pınar, REİS ARAS, Merih, SAĞLAM, Buğra, TIĞLIOĞLU, Mesut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Editora Ltda. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572574/
http://dx.doi.org/10.1016/j.htct.2021.10.979
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author YILMAZ, Fatma
ALBAYRAK, Murat
YILDIZ, Abdülkerim
AFACAN ÖZTÜRK, Hacer Berna
MARAL, Senem
MALKAN, Ümit Yavuz
AKYOL, Pınar
REİS ARAS, Merih
SAĞLAM, Buğra
TIĞLIOĞLU, Mesut
author_facet YILMAZ, Fatma
ALBAYRAK, Murat
YILDIZ, Abdülkerim
AFACAN ÖZTÜRK, Hacer Berna
MARAL, Senem
MALKAN, Ümit Yavuz
AKYOL, Pınar
REİS ARAS, Merih
SAĞLAM, Buğra
TIĞLIOĞLU, Mesut
author_sort YILMAZ, Fatma
collection PubMed
description OBJECTIVE: Coronavirus disease 2019 is an infectious disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clinical and laboratory predictors may identification of patients at risk of mortality and guide treatment .To analyze laboratory abnormalities in patients with COVID-19 and define which parameters affect mortality and hospitalization METHODOLOGY: This retrospective study was conducted on 101 patients diagnosed with COVID-19. Demographic characteristics, laboratory parameters including complete blood count (CBC) parameters, biochemical tests, coagulation parameters, duration of hospitalization and final status (discharge or death) were recorded RESULTS: Comparisons were made of survivors and non-survivors at the end of follow up period.  Multivariate analysis showed mean platelet volume (MPV), platelet distribution width (PDW) and lactate dehydrogenase (LDH) to be significant predictors of mortality. The cut-off value of the hospitalization period was found to be 10 days, so patients were divided into two groups. In the multivariate models, no significant independent parameter was observed for the prediction of hospitalization duration. CONCLUSION: The results of the current study demonstrated that MPV, PDW and LDH were significant independent variables for the prediction of mortality. As SARS-CoV and SARS-CoV-2 are known to use the same receptor, there may be a similar structure and receptor for mutant variants and the first variant, so these predictive parameters can be considered to be as effective in mutant variants.
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spelling pubmed-85725742021-11-08 THE IMPACT OF HEMATOLOGICAL PARAMETERS ON SURVIVAL FOR PATIENTS WITH COVID-19 YILMAZ, Fatma ALBAYRAK, Murat YILDIZ, Abdülkerim AFACAN ÖZTÜRK, Hacer Berna MARAL, Senem MALKAN, Ümit Yavuz AKYOL, Pınar REİS ARAS, Merih SAĞLAM, Buğra TIĞLIOĞLU, Mesut Hematol Transfus Cell Ther Op 11 OBJECTIVE: Coronavirus disease 2019 is an infectious disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clinical and laboratory predictors may identification of patients at risk of mortality and guide treatment .To analyze laboratory abnormalities in patients with COVID-19 and define which parameters affect mortality and hospitalization METHODOLOGY: This retrospective study was conducted on 101 patients diagnosed with COVID-19. Demographic characteristics, laboratory parameters including complete blood count (CBC) parameters, biochemical tests, coagulation parameters, duration of hospitalization and final status (discharge or death) were recorded RESULTS: Comparisons were made of survivors and non-survivors at the end of follow up period.  Multivariate analysis showed mean platelet volume (MPV), platelet distribution width (PDW) and lactate dehydrogenase (LDH) to be significant predictors of mortality. The cut-off value of the hospitalization period was found to be 10 days, so patients were divided into two groups. In the multivariate models, no significant independent parameter was observed for the prediction of hospitalization duration. CONCLUSION: The results of the current study demonstrated that MPV, PDW and LDH were significant independent variables for the prediction of mortality. As SARS-CoV and SARS-CoV-2 are known to use the same receptor, there may be a similar structure and receptor for mutant variants and the first variant, so these predictive parameters can be considered to be as effective in mutant variants. Published by Elsevier Editora Ltda. 2021-11 2021-11-07 /pmc/articles/PMC8572574/ http://dx.doi.org/10.1016/j.htct.2021.10.979 Text en Copyright © 2021 Published by Elsevier Editora Ltda. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Op 11
YILMAZ, Fatma
ALBAYRAK, Murat
YILDIZ, Abdülkerim
AFACAN ÖZTÜRK, Hacer Berna
MARAL, Senem
MALKAN, Ümit Yavuz
AKYOL, Pınar
REİS ARAS, Merih
SAĞLAM, Buğra
TIĞLIOĞLU, Mesut
THE IMPACT OF HEMATOLOGICAL PARAMETERS ON SURVIVAL FOR PATIENTS WITH COVID-19
title THE IMPACT OF HEMATOLOGICAL PARAMETERS ON SURVIVAL FOR PATIENTS WITH COVID-19
title_full THE IMPACT OF HEMATOLOGICAL PARAMETERS ON SURVIVAL FOR PATIENTS WITH COVID-19
title_fullStr THE IMPACT OF HEMATOLOGICAL PARAMETERS ON SURVIVAL FOR PATIENTS WITH COVID-19
title_full_unstemmed THE IMPACT OF HEMATOLOGICAL PARAMETERS ON SURVIVAL FOR PATIENTS WITH COVID-19
title_short THE IMPACT OF HEMATOLOGICAL PARAMETERS ON SURVIVAL FOR PATIENTS WITH COVID-19
title_sort impact of hematological parameters on survival for patients with covid-19
topic Op 11
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572574/
http://dx.doi.org/10.1016/j.htct.2021.10.979
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