Quantitative determination of D(4)-cystine in mice using LC-MS/MS and its application to the assessment of pharmacokinetics and bioavailability

Cystine is the primary source material for the synthesis of glutathione. However, the pharmacokinetics and tissue distribution of cystine are largely unknown. A surrogate analyte D(4)-cystine was employed to generate calibration curves for the determination of levels of D(4)-cystine and endogenous c...

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Detalles Bibliográficos
Autores principales: Li, Shuning, Lu, Zhenyao, Jiao, Li, Zhang, Ran, Hong, Yu, Aa, Jiye, Wang, Guangji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572678/
https://www.ncbi.nlm.nih.gov/pubmed/34765270
http://dx.doi.org/10.1016/j.jpha.2020.08.010

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