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Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota

Berberine (BBR) is an isoquinoline alkaloid extracted from Coptis chinensis that improves diabetes, hyperlipidemia and inflammation. Due to the low oral bioavailability of BBR, its mechanism of action is closely related to the gut microbiota. This study focused on the CYP51 enzyme of intestinal bact...

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Detalles Bibliográficos
Autores principales:	Zhang, Zheng-Wei, Cong, Lin, Peng, Ran, Han, Pei, Ma, Shu-Rong, Pan, Li-Bin, Fu, Jie, Yu, Hang, Wang, Yan, Jiang, Jian-Dong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Xi'an Jiaotong University 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572679/ https://www.ncbi.nlm.nih.gov/pubmed/34765276 http://dx.doi.org/10.1016/j.jpha.2020.10.001

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