Cargando…

Hypoxia blocks ferroptosis of hepatocellular carcinoma via suppression of METTL14 triggered YTHDF2‐dependent silencing of SLC7A11

Residue hepatocellular carcinoma (HCC) cells enduring hypoxic environment triggered by interventional embolization obtain more malignant potential with little clarified mechanism. The N(6)‐methyladenosine (m(6)A) biological activity plays essential roles in diverse physiological processes. However,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fan, Zhuoyang, Yang, Guowei, Zhang, Wei, Liu, Qian, Liu, Guangqin, Liu, Pingping, Xu, Ligang, Wang, Jianhua, Yan, Zhiping, Han, Hong, Liu, Rong, Shu, Minfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572766/ https://www.ncbi.nlm.nih.gov/pubmed/34609072 http://dx.doi.org/10.1111/jcmm.16957

Ejemplares similares

DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus
por: Zhao, Lingcai, et al.
Publicado: (2022)

Curdione induces ferroptosis mediated by m6A methylation via METTL14 and YTHDF2 in colorectal cancer
por: Wang, Fang, et al.
Publicado: (2023)

Novel prognostic biomarkers, METTL14 and YTHDF2, associated with RNA methylation in Ewing’s sarcoma
por: Jiang, Jie, et al.
Publicado: (2022)

METTL14 reverses liver fibrosis by inhibiting NOVA2 through an m(6)A-YTHDF2–dependent mechanism
por: Hou, Xiaoxue, et al.
Publicado: (2023)

METTL9-SLC7A11 axis promotes hepatocellular carcinoma progression through ferroptosis inhibition
por: Bi, Fangfang, et al.
Publicado: (2023)

The study of METTL14, ALKBH5, and YTHDF2 in peripheral blood mononuclear cells from systemic lupus erythematosus
por: Luo, Qing, et al.
Publicado: (2020)

METTL14 promotes prostate tumorigenesis by inhibiting THBS1 via an m6A-YTHDF2-dependent mechanism
por: Wang, Yongjie, et al.
Publicado: (2022)

Analysis of METTL3 and METTL14 in hepatocellular carcinoma
por: Liu, Xiangxiang, et al.
Publicado: (2020)

Hypoxia inducible lncRNA-CBSLR modulates ferroptosis through m6A-YTHDF2-dependent modulation of CBS in gastric cancer
por: Yang, Hui, et al.
Publicado: (2021)

Insights into roles of METTL14 in tumors
por: Liu, Xin, et al.
Publicado: (2021)

METTL3 facilitates immunosurveillance by inhibiting YTHDF2-mediated NLRC5 mRNA degradation in endometrial cancer
por: Zhan, Lei, et al.
Publicado: (2023)

YTHDF1 Promotes Bladder Cancer Cell Proliferation via the METTL3/YTHDF1–RPN2–PI3K/AKT/mTOR Axis
por: Zhu, Junlong, et al.
Publicado: (2023)

N(6)-methyladenosine METTL3 promotes cervical cancer tumorigenesis and Warburg effect through YTHDF1/HK2 modification
por: Wang, Qianqing, et al.
Publicado: (2020)

The Distinct Function and Localization of METTL3/METTL14 and METTL16 Enzymes in Cardiomyocytes
por: Arcidiacono, Orazio Angelo, et al.
Publicado: (2020)

The Comprehensive Analysis of N6-Methyadenosine Writer METTL3 and METTL14 in Gastric Cancer
por: Ge, Yiling, et al.
Publicado: (2023)

METTL3 Facilitates Oral Squamous Cell Carcinoma Tumorigenesis by Enhancing c-Myc Stability via YTHDF1-Mediated m(6)A Modification
por: Zhao, Wei, et al.
Publicado: (2020)

METTL3 promotes cell cycle progression via m(6)A/YTHDF1-dependent regulation of CDC25B translation
por: Li, Huifeng, et al.
Publicado: (2022)

METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m(6)A-YTHDF2-dependent manner
por: Li, Jiaren, et al.
Publicado: (2022)

Novel insights into the METTL3-METTL14 complex in musculoskeletal diseases
por: Xu, Yeqiu, et al.
Publicado: (2023)

METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m(6)A modification
por: Xu, Yiming, et al.
Publicado: (2022)

N6-methyladenosine methylation-related genes YTHDF2, METTL3, and ZC3H13 predict the prognosis of hepatocellular carcinoma patients
por: Wang, Yun, et al.
Publicado: (2022)

RNA Editing Enzyme ADAR1 Regulates METTL3 in an Editing Dependent Manner to Promote Breast Cancer Progression via METTL3/ARHGAP5/YTHDF1 Axis
por: Li, Yi, et al.
Publicado: (2022)

METTL3/YTHDF2 m(6)A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer
por: Xie, Haiyun, et al.
Publicado: (2020)

The study of METTL3 and METTL14 expressions in childhood ETV6/RUNX1‐positive acute lymphoblastic leukemia
por: Sun, Congcong, et al.
Publicado: (2019)

METTL3/YTHDF2 m6A axis accelerates colorectal carcinogenesis through epigenetically suppressing YPEL5
por: Zhou, Dan, et al.
Publicado: (2021)

METTL3/YTHDF2 m6A axis promotes the malignant progression of bladder cancer by epigenetically suppressing RRAS
por: Chen, Jie-Xun, et al.
Publicado: (2023)

Correction: Novel insights into the METTL3-METTL14 complex in musculoskeletal diseases
por: Xu, Yeqiu, et al.
Publicado: (2023)

A METTL3-METTL14 complex mediates mammalian nuclear RNA N(6)-adenosine methylation
por: Liu, Jianzhao, et al.
Publicado: (2013)

Knockdown of SLC39A14 inhibits glioma progression by promoting erastin-induced ferroptosis SLC39A14 knockdown inhibits glioma progression
por: Zhang, Yunwen, et al.
Publicado: (2023)

TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4
por: Wang, Hao, et al.
Publicado: (2021)

Hypoxia-responsive nanoreactors based on self-enhanced photodynamic sensitization and triggered ferroptosis for cancer synergistic therapy
por: Wang, Xiaoyan, et al.
Publicado: (2021)

PRMT1 methylates METTL14 to modulate its oncogenic function
por: Wang, Jingchao, et al.
Publicado: (2023)

METTL3 promotes intrahepatic cholangiocarcinoma progression by regulating IFIT2 expression in an m(6)A-YTHDF2-dependent manner
por: Xu, Qiong-Cong, et al.
Publicado: (2022)

The role, mechanism, and application of RNA methyltransferase METTL14 in gastrointestinal cancer
por: Shi, Bin, et al.
Publicado: (2022)

m(6)A independent genome-wide METTL3 and METTL14 redistribution drives senescence-associated secretory phenotype
por: Liu, Pingyu, et al.
Publicado: (2021)

YTHDF1 promotes mRNA degradation via YTHDF1‐AGO2 interaction and phase separation
por: Li, Jiong, et al.
Publicado: (2021)

HIV Replication Is Increased by RNA Methylation METTL3/METTL14/WTAP Complex Activators
por: Selberg, Simona, et al.
Publicado: (2021)

Roles of the m6A methyltransferases METTL3, METTL14, and WTAP in pulmonary tuberculosis
por: Zhang, Tian-Ping, et al.
Publicado: (2022)

METTL3-regulated m6A modification impairs the decidualization of endometrial stromal cells by regulating YTHDF2-mediated degradation of FOXO1 mRNA in endometriosis-related infertility
por: Li, Xiaoou, et al.
Publicado: (2023)

METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N(6)-methyladenosine-dependent YTHDF binding
por: Wang, Wei, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_v6vibp40gt9v33bp1ukrlpoiqq