Evolutionary coupling-inspired engineering of alcohol dehydrogenase reveals the influence of distant sites on its catalytic efficiency for stereospecific synthesis of chiral alcohols

Alcohol dehydrogenase (ADH) has attracted much attention due to its ability to catalyze the synthesis of important chiral alcohol pharmaceutical intermediates with high stereoselectivity. ADH protein engineering efforts have generally focused on reshaping the substrate-binding pocket. However, dista...

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Detalles Bibliográficos
Autores principales: Gu, Jie, Sim, Byu Ri, Li, Jiarui, Yu, Yangqing, Qin, Lei, Wu, Lunjie, Shen, Yu, Nie, Yao, Zhao, Yi-Lei, Xu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572861/
https://www.ncbi.nlm.nih.gov/pubmed/34815831
http://dx.doi.org/10.1016/j.csbj.2021.10.031

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