Effects of hydroxyurea on cytotoxicity, inflammation and oxidative stress markers in neutrophils of patients with sickle cell anemia: dose-effect relationship

INTRODUCTION: Although the efficacy of hydroxyurea (HU) in inhibiting erythrocyte sickling has been well demonstrated, the action of this drug on human neutrophils and the mechanism by which it improves the manifestations of the disease have not been studied thoroughly. We aimed to investigate the c...

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Detalles Bibliográficos
Autores principales: Pedrosa, Alano Martins, Leal, Luzia Kalyne A.M., Lemes, Romélia Pinheiro G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Hematologia e Hemoterapia 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573033/
https://www.ncbi.nlm.nih.gov/pubmed/33051133
http://dx.doi.org/10.1016/j.htct.2020.07.011

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