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Long-Term Functional Outcomes After Sepsis for Adult and Pediatric Critical Care Patients—Protocol for a Systematic Review

Objective: Sepsis is responsible for a massive burden of disease, with a global estimate of 48.9 million cases resulting in approximately 11 million deaths annually. Survivors of sepsis may also experience long-term impairments that can persist for years after hospital discharge. These cognitive, ph...

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Autores principales: Simpson, Adam, Long, Deborah, Fleischmann-Struzek, Carolin, Minogue, Jessicah, Venkatesh, Balasubramanian, Hammond, Naomi E., Tian, David H., Schlapbach, Luregn J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573219/
https://www.ncbi.nlm.nih.gov/pubmed/34760851
http://dx.doi.org/10.3389/fped.2021.734205
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author Simpson, Adam
Long, Deborah
Fleischmann-Struzek, Carolin
Minogue, Jessicah
Venkatesh, Balasubramanian
Hammond, Naomi E.
Tian, David H.
Schlapbach, Luregn J.
author_facet Simpson, Adam
Long, Deborah
Fleischmann-Struzek, Carolin
Minogue, Jessicah
Venkatesh, Balasubramanian
Hammond, Naomi E.
Tian, David H.
Schlapbach, Luregn J.
author_sort Simpson, Adam
collection PubMed
description Objective: Sepsis is responsible for a massive burden of disease, with a global estimate of 48.9 million cases resulting in approximately 11 million deaths annually. Survivors of sepsis may also experience long-term impairments that can persist for years after hospital discharge. These cognitive, physical and/or psychosocial deficits may contribute to a lower health related quality of life and represent a significant ongoing burden to the individual, the community and the health care system. We aim to systematically review the available evidence on long-term functional and quality of life outcomes after sepsis in children and adults. Data Sources: Medline, EMBASE, and CINAHL will be searched for eligible studies. Study Selection: Studies of adult and pediatric survivors of sepsis who had required admission to intensive care will be included. A minimum 6 month prospective follow up will be required. Accepted outcomes will be any validated measure of health-related quality of life (HRQoL) or functional deficits, using the Post-Intensive Care Syndrome (PICS) framework of cognitive, physical or psychosocial outcomes. Data Extraction: Data extraction will include information related to study characteristics, population characteristics, clinical criteria and outcomes. Data Synthesis: Studies meeting the inclusion criteria will be presented descriptively separated for pediatric and adult age groups. Meta-analysis will be attempted if sufficient primary data from several studies applying the same tests and outcomes are available. The primary outcome is HRQoL after sepsis; secondary outcomes include the functional status at follow-up. Conclusions: This systematic review will define the long-term impact of sepsis survivorship. The data will contribute to informing patient, clinician and stakeholder decisions and guide further research and resource management.
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spelling pubmed-85732192021-11-09 Long-Term Functional Outcomes After Sepsis for Adult and Pediatric Critical Care Patients—Protocol for a Systematic Review Simpson, Adam Long, Deborah Fleischmann-Struzek, Carolin Minogue, Jessicah Venkatesh, Balasubramanian Hammond, Naomi E. Tian, David H. Schlapbach, Luregn J. Front Pediatr Pediatrics Objective: Sepsis is responsible for a massive burden of disease, with a global estimate of 48.9 million cases resulting in approximately 11 million deaths annually. Survivors of sepsis may also experience long-term impairments that can persist for years after hospital discharge. These cognitive, physical and/or psychosocial deficits may contribute to a lower health related quality of life and represent a significant ongoing burden to the individual, the community and the health care system. We aim to systematically review the available evidence on long-term functional and quality of life outcomes after sepsis in children and adults. Data Sources: Medline, EMBASE, and CINAHL will be searched for eligible studies. Study Selection: Studies of adult and pediatric survivors of sepsis who had required admission to intensive care will be included. A minimum 6 month prospective follow up will be required. Accepted outcomes will be any validated measure of health-related quality of life (HRQoL) or functional deficits, using the Post-Intensive Care Syndrome (PICS) framework of cognitive, physical or psychosocial outcomes. Data Extraction: Data extraction will include information related to study characteristics, population characteristics, clinical criteria and outcomes. Data Synthesis: Studies meeting the inclusion criteria will be presented descriptively separated for pediatric and adult age groups. Meta-analysis will be attempted if sufficient primary data from several studies applying the same tests and outcomes are available. The primary outcome is HRQoL after sepsis; secondary outcomes include the functional status at follow-up. Conclusions: This systematic review will define the long-term impact of sepsis survivorship. The data will contribute to informing patient, clinician and stakeholder decisions and guide further research and resource management. Frontiers Media S.A. 2021-10-25 /pmc/articles/PMC8573219/ /pubmed/34760851 http://dx.doi.org/10.3389/fped.2021.734205 Text en Copyright © 2021 Simpson, Long, Fleischmann-Struzek, Minogue, Venkatesh, Hammond, Tian and Schlapbach. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Simpson, Adam
Long, Deborah
Fleischmann-Struzek, Carolin
Minogue, Jessicah
Venkatesh, Balasubramanian
Hammond, Naomi E.
Tian, David H.
Schlapbach, Luregn J.
Long-Term Functional Outcomes After Sepsis for Adult and Pediatric Critical Care Patients—Protocol for a Systematic Review
title Long-Term Functional Outcomes After Sepsis for Adult and Pediatric Critical Care Patients—Protocol for a Systematic Review
title_full Long-Term Functional Outcomes After Sepsis for Adult and Pediatric Critical Care Patients—Protocol for a Systematic Review
title_fullStr Long-Term Functional Outcomes After Sepsis for Adult and Pediatric Critical Care Patients—Protocol for a Systematic Review
title_full_unstemmed Long-Term Functional Outcomes After Sepsis for Adult and Pediatric Critical Care Patients—Protocol for a Systematic Review
title_short Long-Term Functional Outcomes After Sepsis for Adult and Pediatric Critical Care Patients—Protocol for a Systematic Review
title_sort long-term functional outcomes after sepsis for adult and pediatric critical care patients—protocol for a systematic review
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573219/
https://www.ncbi.nlm.nih.gov/pubmed/34760851
http://dx.doi.org/10.3389/fped.2021.734205
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