A new strategy to increase RNA editing at the Q/R site of GluA2 AMPA receptor subunits by targeting alternative splicing patterns of ADAR2

BACKGROUND: The GluA2 subunit of AMPA receptors (AMPARs) undergoes RNA editing at a specific base mediated by the enzyme ADAR2, changing the coded amino acid from a glutamine to arginine at the so-called Q/R site, which is critical for regulating calcium permeability. ADAR2 exists as multiple altern...

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Detalles Bibliográficos
Autores principales: Chaytow, Helena, Sethw Hassan, Ilda, Akbar, Sara, Popplewell, Linda, Dickson, George, Chen, Philip E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier/North-Holland Biomedical Press 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573265/
https://www.ncbi.nlm.nih.gov/pubmed/34536489
http://dx.doi.org/10.1016/j.jneumeth.2021.109357

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