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Iguratimod Alleviates Myocardial Ischemia/Reperfusion Injury Through Inhibiting Inflammatory Response Induced by Cardiac Fibroblast Pyroptosis via COX2/NLRP3 Signaling Pathway

Background: NLRP3 inflammasome contributes a lot to sterile inflammatory response and pyroptosis in ischemia/reperfusion (I/R) injury. Cardiac fibroblasts (CFs) are regarded as semi-professional inflammatory cells and they exert an immunomodulatory role in heart. Iguratimod provides a protective rol...

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Detalles Bibliográficos
Autores principales:	Zhang, Mian, Lei, Yi-shan, Meng, Xiao-wen, Liu, Hua-yue, Li, Lin-gui, Zhang, Jun, Zhang, Jia-xin, Tao, Wen-hui, Peng, Ke, Lin, Jun, Ji, Fu-hai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573346/ https://www.ncbi.nlm.nih.gov/pubmed/34760889 http://dx.doi.org/10.3389/fcell.2021.746317

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