Milking the Cow: Cattle-Derived Chimeric Ultralong CDR-H3 Antibodies and Their Engineered CDR-H3-Only Knobbody Counterparts Targeting Epidermal Growth Factor Receptor Elicit Potent NK Cell-Mediated Cytotoxicity

In this work, we have generated epidermal growth factor receptor (EGFR)-specific cattle-derived ultralong CDR-H3 antibodies by combining cattle immunization with yeast surface display. After immunization, ultralong CDR-H3 regions were specifically amplified and grafted onto an IGHV1-7 scaffold by ho...

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Detalles Bibliográficos
Autores principales: Pekar, Lukas, Klewinghaus, Daniel, Arras, Paul, Carrara, Stefania C., Harwardt, Julia, Krah, Simon, Yanakieva, Desislava, Toleikis, Lars, Smider, Vaughn V., Kolmar, Harald, Zielonka, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573386/
https://www.ncbi.nlm.nih.gov/pubmed/34759924
http://dx.doi.org/10.3389/fimmu.2021.742418

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