Cargando…

ATARI trial: ATR inhibitor in combination with olaparib in gynecological cancers with ARID1A loss or no loss (ENGOT/GYN1/NCRI)

BACKGROUND: ARID1A (AT-rich interactive domain containing protein 1A) loss-of-function mutations have been reported in gynecological cancers, including rarer subtypes such as clear cell carcinoma. Preclinical studies indicate that ARID1A mutant cancers display sensitivity to ATR inhibition while tum...

Descripción completa

Detalles Bibliográficos
Autores principales:	Banerjee, Susana, Stewart, James, Porta, Nuria, Toms, Christy, Leary, Alexandra, Lheureux, Stephanie, Khalique, Saira, Tai, Jeremy, Attygalle, Ayoma, Vroobel, Katherine, Lord, Christopher J, Natrajan, Rachael, Bliss, Judith
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Clinical Trial
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573414/ https://www.ncbi.nlm.nih.gov/pubmed/34518240 http://dx.doi.org/10.1136/ijgc-2021-002973

Ejemplares similares

Optimised ARID1A immunohistochemistry is an accurate predictor of ARID1A mutational status in gynaecological cancers
por: Khalique, Saira, et al.
Publicado: (2018)

Definitive study shows no association between ARID1A mutation status and clinical outcome in endometriosis‐related ovarian cancers
por: Khalique, Saira, et al.
Publicado: (2022)

Discordance between positron emission tomography standard uptake value and proliferation index in mantle cell lymphoma: An initial communication
por: Renn, Alexandra, et al.
Publicado: (2021)

Benchmarking Perturbation-Based Saliency Maps for Explaining Atari Agents
por: Huber, Tobias, et al.
Publicado: (2022)

OB/GYN secrets /
Publicado: (2003)

Olaparib plus bevacizumab as maintenance therapy in patients with newly diagnosed, advanced ovarian cancer: Japan subset from the PAOLA-1/ENGOT-ov25 trial
por: Fujiwara, Keiichi, et al.
Publicado: (2021)

Homologous Recombination Repair Gene Mutations to Predict Olaparib Plus Bevacizumab Efficacy in the First-Line Ovarian Cancer PAOLA-1/ENGOT-ov25 Trial
por: Pujade-Lauraine, Eric, et al.
Publicado: (2023)

Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA
por: Menolfi, Demis, et al.
Publicado: (2018)

ATARiS: Computational quantification of gene suppression phenotypes from multisample RNAi screens
por: Shao, Diane D., et al.
Publicado: (2013)

Ceralasertib-Mediated ATR Inhibition Combined With Olaparib in Advanced Cancers Harboring DNA Damage Response and Repair Alterations (Olaparib Combinations)
por: Mahdi, Haider, et al.
Publicado: (2021)

Olaparib Combined with an ATR or Chk1 Inhibitor as a Treatment Strategy for Acquired Olaparib-Resistant BRCA1 Mutant Ovarian Cells
por: Burgess, Brian T., et al.
Publicado: (2020)

Study to Address Threats of Acute Respiratory Infections among Congregate Military Populations (ATARI)
por: Coles, Christian, et al.
Publicado: (2017)

Cancer Informatics in the U.K.: The NCRI Informatics Initiative
por: Reddington, Fiona, et al.
Publicado: (2007)

Dual blockade of BRD4 and ATR/WEE1 pathways exploits ARID1A loss in clear cell ovarian cancer
por: Kinose, Yasuto, et al.
Publicado: (2023)

Combinations of ATR, Chk1 and Wee1 Inhibitors with Olaparib Are Active in Olaparib Resistant Brca1 Proficient and Deficient Murine Ovarian Cells
por: Chiappa, Michela, et al.
Publicado: (2022)

ATARI: A Graph Convolutional Neural Network Approach for Performance Prediction in Next-Generation WLANs
por: Soto, Paola, et al.
Publicado: (2021)

ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A
por: Williamson, Chris T., et al.
Publicado: (2016)

Gyn/Ecology: the metaethics of radical feminism
por: Browne, Janet
Publicado: (1981)

An Introduction to Cystoscopy for OB/GYN Residents
por: Shah, Nayan, et al.
Publicado: (2022)

New Partner Recruitment to Rural Versus Urban Ob-Gyn Practices: A Survey of Practicing Ob-Gyns
por: Fialkow, Michael F., et al.
Publicado: (2017)

Loop-Mediated Isothermal Amplification Assay for Detecting Tumor Markers and Human Papillomavirus: Accuracy and Supplemental Diagnostic Value to Endovaginal MRI in Cervical Cancer
por: Wormald, Benjamin, et al.
Publicado: (2021)

Playing Atari with few neurons: Improving the efficacy of reinforcement learning by decoupling feature extraction and decision making
por: Cuccu, Giuseppe, et al.
Publicado: (2021)

Quantitative Assessment and Prognostic Associations of the Immune Landscape in Ovarian Clear Cell Carcinoma
por: Khalique, Saira, et al.
Publicado: (2021)

Longitudinal analysis of a secondary BRCA2 mutation using digital droplet PCR
por: Khalique, Saira, et al.
Publicado: (2019)

Durable response to olaparib in pancreatic duct adenocarcinoma with deleterious ARID1A mutation
por: Zhao, Xue-Song, et al.
Publicado: (2019)

Race and satisfaction in general OB/GYN clinics
por: Rohrer, James E, et al.
Publicado: (2005)

Olaparib significantly delays photoreceptor loss in a model for hereditary retinal degeneration
por: Sahaboglu, Ayse, et al.
Publicado: (2016)

Vintage game consoles: an inside look at Apple, Atari, Commodore, Nintendo, and the greatest gaming platforms of all time
por: Loguidice, Bill, et al.
Publicado: (2014)

Mature T-Cell leukemias: Challenges in Diagnosis
por: El-Sharkawi, Dima, et al.
Publicado: (2022)

ATR Inhibitor AZD6738 (Ceralasertib) Exerts Antitumor Activity as a Monotherapy and in Combination with Chemotherapy and the PARP Inhibitor Olaparib
por: Wilson, Zena, et al.
Publicado: (2022)

Parallel evolution of two distinct lymphoid proliferations in clonal haematopoiesis
por: Attygalle, Ayoma D, et al.
Publicado: (2022)

Selected Abstracts from the 2018 NCRI Cancer Conference of National Cancer Research Institute
Publicado: (2018)

Selected Abstracts from the 2019 NCRI Cancer Conference of National Cancer Research Institute
Publicado: (2019)

Preparedness of Ob/Gyn residents for fellowship training in gynecologic oncology
por: Doo, David W., et al.
Publicado: (2015)

A screening and brief intervention for women in OB/GYN care
por: Balachova, Tatiana, et al.
Publicado: (2015)

Benefits and Barriers to Teaching Medical Students in an Ob-Gyn Clinic
por: Fialkow, Michael F., et al.
Publicado: (2018)

Perception and Comfort with Endometriosis Management Among OB/GYN Residents
por: Sullender, Renee T, et al.
Publicado: (2023)

Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination With Carboplatin in Patients With Advanced Solid Tumors
por: Yap, Timothy A., et al.
Publicado: (2020)

SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance
por: Llorca-Cardenosa, Marta J., et al.
Publicado: (2022)

Olaparib-Resistant BRCA2(MUT) Ovarian Cancer Cells with Restored BRCA2 Abrogate Olaparib-Induced DNA Damage and G2/M Arrest Controlled by the ATR/CHK1 Pathway for Survival
por: Biegała, Łukasz, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_i1bbshtechbmsn0gjo4shull2j