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Link between MnSOD Ala16Val (rs4880) polymorphism and asthma risk is insignificant from sequential meta-analysis

The mitochondrial manganese superoxide dismutase (MnSOD) enzyme protects lungs against oxidative stress by neutralizing the free radical superoxide produced in the respiratory function. This has relevance to asthma. Therefore, it is of interest to describe the potential effect of MnSOD Ala16Val gene...

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Autores principales: Alhobeira, Hazza A, Mandal, Raju K, Khan, Saif, Dar, Sajad A, Mahto, Harishankar, Saeed, Mohd, Wahid, Mohd, Lohani, Mohtashim, Khan, Mahvish, Haque, Shafiul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573465/
https://www.ncbi.nlm.nih.gov/pubmed/34803251
http://dx.doi.org/10.6026/97320630016789
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author Alhobeira, Hazza A
Mandal, Raju K
Khan, Saif
Dar, Sajad A
Mahto, Harishankar
Saeed, Mohd
Wahid, Mohd
Lohani, Mohtashim
Khan, Mahvish
Haque, Shafiul
author_facet Alhobeira, Hazza A
Mandal, Raju K
Khan, Saif
Dar, Sajad A
Mahto, Harishankar
Saeed, Mohd
Wahid, Mohd
Lohani, Mohtashim
Khan, Mahvish
Haque, Shafiul
author_sort Alhobeira, Hazza A
collection PubMed
description The mitochondrial manganese superoxide dismutase (MnSOD) enzyme protects lungs against oxidative stress by neutralizing the free radical superoxide produced in the respiratory function. This has relevance to asthma. Therefore, it is of interest to describe the potential effect of MnSOD Ala16Val genetic polymorphism to asthma risk. Known data in this context is inconclusive in nature. The possible link between MnSOD Ala16Val polymorphism and asthma is explored using sequence meta-analysis. Data from the pooled analysis of MnSOD Ala16Val polymorphism using five genetic models i.e., allelic (Val vs. Ala: p=0.846; OR=1.033, 95% CI=0.742 to 1.440) is discussed. Homozygous (Val Val vs. Ala Ala: p=0.517; OR=1.307, 95% CI=0.582 to 2.932) and heterozygous (Val Ala vs. Ala Ala: p=0.307; OR=1.138, 95% CI=0.888 to 1.459) data using the described models are documented. Data from the dominant model (Val Val + Val Ala vs. Ala Ala: p=0.301; OR=1.289, 95% CI=0.797 to 2.085) and the recessive model (Val Val vs. Val Ala + Ala Ala: p=0.761; OR=0.924, 95% CI=0.555 to 1.538) analyses for several ethnic subgroups in this context is reported.
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spelling pubmed-85734652021-11-18 Link between MnSOD Ala16Val (rs4880) polymorphism and asthma risk is insignificant from sequential meta-analysis Alhobeira, Hazza A Mandal, Raju K Khan, Saif Dar, Sajad A Mahto, Harishankar Saeed, Mohd Wahid, Mohd Lohani, Mohtashim Khan, Mahvish Haque, Shafiul Bioinformation Research Article The mitochondrial manganese superoxide dismutase (MnSOD) enzyme protects lungs against oxidative stress by neutralizing the free radical superoxide produced in the respiratory function. This has relevance to asthma. Therefore, it is of interest to describe the potential effect of MnSOD Ala16Val genetic polymorphism to asthma risk. Known data in this context is inconclusive in nature. The possible link between MnSOD Ala16Val polymorphism and asthma is explored using sequence meta-analysis. Data from the pooled analysis of MnSOD Ala16Val polymorphism using five genetic models i.e., allelic (Val vs. Ala: p=0.846; OR=1.033, 95% CI=0.742 to 1.440) is discussed. Homozygous (Val Val vs. Ala Ala: p=0.517; OR=1.307, 95% CI=0.582 to 2.932) and heterozygous (Val Ala vs. Ala Ala: p=0.307; OR=1.138, 95% CI=0.888 to 1.459) data using the described models are documented. Data from the dominant model (Val Val + Val Ala vs. Ala Ala: p=0.301; OR=1.289, 95% CI=0.797 to 2.085) and the recessive model (Val Val vs. Val Ala + Ala Ala: p=0.761; OR=0.924, 95% CI=0.555 to 1.538) analyses for several ethnic subgroups in this context is reported. Biomedical Informatics 2020-11-30 /pmc/articles/PMC8573465/ /pubmed/34803251 http://dx.doi.org/10.6026/97320630016789 Text en © 2020 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research Article
Alhobeira, Hazza A
Mandal, Raju K
Khan, Saif
Dar, Sajad A
Mahto, Harishankar
Saeed, Mohd
Wahid, Mohd
Lohani, Mohtashim
Khan, Mahvish
Haque, Shafiul
Link between MnSOD Ala16Val (rs4880) polymorphism and asthma risk is insignificant from sequential meta-analysis
title Link between MnSOD Ala16Val (rs4880) polymorphism and asthma risk is insignificant from sequential meta-analysis
title_full Link between MnSOD Ala16Val (rs4880) polymorphism and asthma risk is insignificant from sequential meta-analysis
title_fullStr Link between MnSOD Ala16Val (rs4880) polymorphism and asthma risk is insignificant from sequential meta-analysis
title_full_unstemmed Link between MnSOD Ala16Val (rs4880) polymorphism and asthma risk is insignificant from sequential meta-analysis
title_short Link between MnSOD Ala16Val (rs4880) polymorphism and asthma risk is insignificant from sequential meta-analysis
title_sort link between mnsod ala16val (rs4880) polymorphism and asthma risk is insignificant from sequential meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573465/
https://www.ncbi.nlm.nih.gov/pubmed/34803251
http://dx.doi.org/10.6026/97320630016789
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