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Siponimod (BAF312) penetrates, distributes, and acts in the central nervous system: Preclinical insights
BACKGROUND: Siponimod (BAF312), a selective S1P(1)/S1P(5) agonist, reduces disability progression in secondary progressive MS. Recent observations suggest it could act via S1P(1)/S1P(5)-dependent anti-inflammatory and pro-myelination effects on CNS-resident cells. OBJECTIVE: Generate preclinical evi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573504/ https://www.ncbi.nlm.nih.gov/pubmed/34777855 http://dx.doi.org/10.1177/20552173211049168 |