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Benefits of prescribing low-dose digoxin in atrial fibrillation

INTRODUCTION: The role of digoxin (cardiac glycoside) in controlling the heart rate (HR) for the treatment of atrial fibrillation (AF) patients has not been explored in depth. METHODS: To contribute to the limited data, our team conducted retrospective analysis of the clinical records of 1444 AF pat...

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Autores principales: Rosca, Ciprian Ilie, Kundnani, Nilima Rajpal, Tudor, Anca, Rosca, Maria-Silvia, Nicoras, Violeta-Ariana, Otiman, Gabriela, Ciurariu, Elena, Ionescu, Alin, Stelian, Morariu, Sharma, Abhinav, Borza, Claudia, Lighezan, Daniel Florin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573519/
https://www.ncbi.nlm.nih.gov/pubmed/34724841
http://dx.doi.org/10.1177/20587384211051955
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author Rosca, Ciprian Ilie
Kundnani, Nilima Rajpal
Tudor, Anca
Rosca, Maria-Silvia
Nicoras, Violeta-Ariana
Otiman, Gabriela
Ciurariu, Elena
Ionescu, Alin
Stelian, Morariu
Sharma, Abhinav
Borza, Claudia
Lighezan, Daniel Florin
author_facet Rosca, Ciprian Ilie
Kundnani, Nilima Rajpal
Tudor, Anca
Rosca, Maria-Silvia
Nicoras, Violeta-Ariana
Otiman, Gabriela
Ciurariu, Elena
Ionescu, Alin
Stelian, Morariu
Sharma, Abhinav
Borza, Claudia
Lighezan, Daniel Florin
author_sort Rosca, Ciprian Ilie
collection PubMed
description INTRODUCTION: The role of digoxin (cardiac glycoside) in controlling the heart rate (HR) for the treatment of atrial fibrillation (AF) patients has not been explored in depth. METHODS: To contribute to the limited data, our team conducted retrospective analysis of the clinical records of 1444 AF patients. We divided the AF patients into two groups, wherein group 1 patients were treated with beta-blockers (BB), low-dose digoxin, and an anticoagulant (vitamin K antagonist/factor-IIa inhibitor/factor-Xa inhibitor), and group 2 patients were treated with just BB and an anticoagulant. Our objectives were to compare the impact of combination therapy of BB and digoxin on the resting HR in patients with permanent AF and the patients’ quality of life (QOL) at periodic intervals. RESULTS: The findings of our study showed a better control of the resting HR rate (<110bpm) and an improved QOL among the group 1 patients when compared with group 2 patients. CONCLUSION: Our findings are indicative of the favorable clinical outcomes that resulted from the addition of a low-dose of digoxin to the AF treatment regimen. However, larger studies/trials elucidating the outcomes of AF patients treated with the dual rate control therapy are required, to clarify the role of digoxin, guide the choice of agents, and standardize the AF treatment protocol.
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spelling pubmed-85735192021-11-09 Benefits of prescribing low-dose digoxin in atrial fibrillation Rosca, Ciprian Ilie Kundnani, Nilima Rajpal Tudor, Anca Rosca, Maria-Silvia Nicoras, Violeta-Ariana Otiman, Gabriela Ciurariu, Elena Ionescu, Alin Stelian, Morariu Sharma, Abhinav Borza, Claudia Lighezan, Daniel Florin Int J Immunopathol Pharmacol Original Research Article INTRODUCTION: The role of digoxin (cardiac glycoside) in controlling the heart rate (HR) for the treatment of atrial fibrillation (AF) patients has not been explored in depth. METHODS: To contribute to the limited data, our team conducted retrospective analysis of the clinical records of 1444 AF patients. We divided the AF patients into two groups, wherein group 1 patients were treated with beta-blockers (BB), low-dose digoxin, and an anticoagulant (vitamin K antagonist/factor-IIa inhibitor/factor-Xa inhibitor), and group 2 patients were treated with just BB and an anticoagulant. Our objectives were to compare the impact of combination therapy of BB and digoxin on the resting HR in patients with permanent AF and the patients’ quality of life (QOL) at periodic intervals. RESULTS: The findings of our study showed a better control of the resting HR rate (<110bpm) and an improved QOL among the group 1 patients when compared with group 2 patients. CONCLUSION: Our findings are indicative of the favorable clinical outcomes that resulted from the addition of a low-dose of digoxin to the AF treatment regimen. However, larger studies/trials elucidating the outcomes of AF patients treated with the dual rate control therapy are required, to clarify the role of digoxin, guide the choice of agents, and standardize the AF treatment protocol. SAGE Publications 2021-11-01 /pmc/articles/PMC8573519/ /pubmed/34724841 http://dx.doi.org/10.1177/20587384211051955 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Article
Rosca, Ciprian Ilie
Kundnani, Nilima Rajpal
Tudor, Anca
Rosca, Maria-Silvia
Nicoras, Violeta-Ariana
Otiman, Gabriela
Ciurariu, Elena
Ionescu, Alin
Stelian, Morariu
Sharma, Abhinav
Borza, Claudia
Lighezan, Daniel Florin
Benefits of prescribing low-dose digoxin in atrial fibrillation
title Benefits of prescribing low-dose digoxin in atrial fibrillation
title_full Benefits of prescribing low-dose digoxin in atrial fibrillation
title_fullStr Benefits of prescribing low-dose digoxin in atrial fibrillation
title_full_unstemmed Benefits of prescribing low-dose digoxin in atrial fibrillation
title_short Benefits of prescribing low-dose digoxin in atrial fibrillation
title_sort benefits of prescribing low-dose digoxin in atrial fibrillation
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573519/
https://www.ncbi.nlm.nih.gov/pubmed/34724841
http://dx.doi.org/10.1177/20587384211051955
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