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Benefits of prescribing low-dose digoxin in atrial fibrillation
INTRODUCTION: The role of digoxin (cardiac glycoside) in controlling the heart rate (HR) for the treatment of atrial fibrillation (AF) patients has not been explored in depth. METHODS: To contribute to the limited data, our team conducted retrospective analysis of the clinical records of 1444 AF pat...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573519/ https://www.ncbi.nlm.nih.gov/pubmed/34724841 http://dx.doi.org/10.1177/20587384211051955 |
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author | Rosca, Ciprian Ilie Kundnani, Nilima Rajpal Tudor, Anca Rosca, Maria-Silvia Nicoras, Violeta-Ariana Otiman, Gabriela Ciurariu, Elena Ionescu, Alin Stelian, Morariu Sharma, Abhinav Borza, Claudia Lighezan, Daniel Florin |
author_facet | Rosca, Ciprian Ilie Kundnani, Nilima Rajpal Tudor, Anca Rosca, Maria-Silvia Nicoras, Violeta-Ariana Otiman, Gabriela Ciurariu, Elena Ionescu, Alin Stelian, Morariu Sharma, Abhinav Borza, Claudia Lighezan, Daniel Florin |
author_sort | Rosca, Ciprian Ilie |
collection | PubMed |
description | INTRODUCTION: The role of digoxin (cardiac glycoside) in controlling the heart rate (HR) for the treatment of atrial fibrillation (AF) patients has not been explored in depth. METHODS: To contribute to the limited data, our team conducted retrospective analysis of the clinical records of 1444 AF patients. We divided the AF patients into two groups, wherein group 1 patients were treated with beta-blockers (BB), low-dose digoxin, and an anticoagulant (vitamin K antagonist/factor-IIa inhibitor/factor-Xa inhibitor), and group 2 patients were treated with just BB and an anticoagulant. Our objectives were to compare the impact of combination therapy of BB and digoxin on the resting HR in patients with permanent AF and the patients’ quality of life (QOL) at periodic intervals. RESULTS: The findings of our study showed a better control of the resting HR rate (<110bpm) and an improved QOL among the group 1 patients when compared with group 2 patients. CONCLUSION: Our findings are indicative of the favorable clinical outcomes that resulted from the addition of a low-dose of digoxin to the AF treatment regimen. However, larger studies/trials elucidating the outcomes of AF patients treated with the dual rate control therapy are required, to clarify the role of digoxin, guide the choice of agents, and standardize the AF treatment protocol. |
format | Online Article Text |
id | pubmed-8573519 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-85735192021-11-09 Benefits of prescribing low-dose digoxin in atrial fibrillation Rosca, Ciprian Ilie Kundnani, Nilima Rajpal Tudor, Anca Rosca, Maria-Silvia Nicoras, Violeta-Ariana Otiman, Gabriela Ciurariu, Elena Ionescu, Alin Stelian, Morariu Sharma, Abhinav Borza, Claudia Lighezan, Daniel Florin Int J Immunopathol Pharmacol Original Research Article INTRODUCTION: The role of digoxin (cardiac glycoside) in controlling the heart rate (HR) for the treatment of atrial fibrillation (AF) patients has not been explored in depth. METHODS: To contribute to the limited data, our team conducted retrospective analysis of the clinical records of 1444 AF patients. We divided the AF patients into two groups, wherein group 1 patients were treated with beta-blockers (BB), low-dose digoxin, and an anticoagulant (vitamin K antagonist/factor-IIa inhibitor/factor-Xa inhibitor), and group 2 patients were treated with just BB and an anticoagulant. Our objectives were to compare the impact of combination therapy of BB and digoxin on the resting HR in patients with permanent AF and the patients’ quality of life (QOL) at periodic intervals. RESULTS: The findings of our study showed a better control of the resting HR rate (<110bpm) and an improved QOL among the group 1 patients when compared with group 2 patients. CONCLUSION: Our findings are indicative of the favorable clinical outcomes that resulted from the addition of a low-dose of digoxin to the AF treatment regimen. However, larger studies/trials elucidating the outcomes of AF patients treated with the dual rate control therapy are required, to clarify the role of digoxin, guide the choice of agents, and standardize the AF treatment protocol. SAGE Publications 2021-11-01 /pmc/articles/PMC8573519/ /pubmed/34724841 http://dx.doi.org/10.1177/20587384211051955 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Article Rosca, Ciprian Ilie Kundnani, Nilima Rajpal Tudor, Anca Rosca, Maria-Silvia Nicoras, Violeta-Ariana Otiman, Gabriela Ciurariu, Elena Ionescu, Alin Stelian, Morariu Sharma, Abhinav Borza, Claudia Lighezan, Daniel Florin Benefits of prescribing low-dose digoxin in atrial fibrillation |
title | Benefits of prescribing low-dose digoxin in atrial fibrillation |
title_full | Benefits of prescribing low-dose digoxin in atrial fibrillation |
title_fullStr | Benefits of prescribing low-dose digoxin in atrial fibrillation |
title_full_unstemmed | Benefits of prescribing low-dose digoxin in atrial fibrillation |
title_short | Benefits of prescribing low-dose digoxin in atrial fibrillation |
title_sort | benefits of prescribing low-dose digoxin in atrial fibrillation |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573519/ https://www.ncbi.nlm.nih.gov/pubmed/34724841 http://dx.doi.org/10.1177/20587384211051955 |
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