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Behavioral Tasks Evaluating Schizophrenia-like Symptoms in Animal Models: A Recent Update
BACKGROUND: Schizophrenia is a serious mental illness that affects more than 21 million people worldwide. Both genetics and the environment play a role in its etiology and pathogenesis. Symptoms of schizophrenia are mainly categorized into positive, negative, and cognitive. One major approach to ide...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Bentham Science Publishers
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573744/ https://www.ncbi.nlm.nih.gov/pubmed/32798374 http://dx.doi.org/10.2174/1570159X18666200814175114 |
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author | Ang, Mary Jasmin Lee, Sueun Kim, Jong-Choon Kim, Sung-Ho Moon, Changjong |
author_facet | Ang, Mary Jasmin Lee, Sueun Kim, Jong-Choon Kim, Sung-Ho Moon, Changjong |
author_sort | Ang, Mary Jasmin |
collection | PubMed |
description | BACKGROUND: Schizophrenia is a serious mental illness that affects more than 21 million people worldwide. Both genetics and the environment play a role in its etiology and pathogenesis. Symptoms of schizophrenia are mainly categorized into positive, negative, and cognitive. One major approach to identify and understand these diverse symptoms in humans has been to study behavioral phenotypes in a range of animal models of schizophrenia. OBJECTIVE: We aimed to provide a comprehensive review of the behavioral tasks commonly used for measuring schizophrenia-like behaviors in rodents together with an update of the recent study findings. METHODS: Articles describing phenotypes of schizophrenia-like behaviors in various animal models were collected through a literature search in Google Scholar, PubMed, Web of Science, and Scopus, with a focus on advances over the last 10 years. RESULTS: Numerous studies have used a range of animal models and behavioral paradigms of schizophrenia to develop antipsychotic drugs for improved therapeutics. In establishing animal models of schizophrenia, the candidate models were evaluated for schizophrenia-like behaviors using several behavioral tasks for positive, negative, and cognitive symptoms designed to verify human symptoms of schizophrenia. Such validated animal models were provided as rapid preclinical avenues for drug testing and mechanistic studies. CONCLUSION: Based on the most recent advances in the field, it is apparent that a myriad of behavior tests are needed to confirm and evaluate the congruency of animal models with the numerous behaviors and clinical signs exhibited by patients with schizophrenia. |
format | Online Article Text |
id | pubmed-8573744 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-85737442021-12-01 Behavioral Tasks Evaluating Schizophrenia-like Symptoms in Animal Models: A Recent Update Ang, Mary Jasmin Lee, Sueun Kim, Jong-Choon Kim, Sung-Ho Moon, Changjong Curr Neuropharmacol Article BACKGROUND: Schizophrenia is a serious mental illness that affects more than 21 million people worldwide. Both genetics and the environment play a role in its etiology and pathogenesis. Symptoms of schizophrenia are mainly categorized into positive, negative, and cognitive. One major approach to identify and understand these diverse symptoms in humans has been to study behavioral phenotypes in a range of animal models of schizophrenia. OBJECTIVE: We aimed to provide a comprehensive review of the behavioral tasks commonly used for measuring schizophrenia-like behaviors in rodents together with an update of the recent study findings. METHODS: Articles describing phenotypes of schizophrenia-like behaviors in various animal models were collected through a literature search in Google Scholar, PubMed, Web of Science, and Scopus, with a focus on advances over the last 10 years. RESULTS: Numerous studies have used a range of animal models and behavioral paradigms of schizophrenia to develop antipsychotic drugs for improved therapeutics. In establishing animal models of schizophrenia, the candidate models were evaluated for schizophrenia-like behaviors using several behavioral tasks for positive, negative, and cognitive symptoms designed to verify human symptoms of schizophrenia. Such validated animal models were provided as rapid preclinical avenues for drug testing and mechanistic studies. CONCLUSION: Based on the most recent advances in the field, it is apparent that a myriad of behavior tests are needed to confirm and evaluate the congruency of animal models with the numerous behaviors and clinical signs exhibited by patients with schizophrenia. Bentham Science Publishers 2021-04-29 2021-04-29 /pmc/articles/PMC8573744/ /pubmed/32798374 http://dx.doi.org/10.2174/1570159X18666200814175114 Text en © 2021 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Ang, Mary Jasmin Lee, Sueun Kim, Jong-Choon Kim, Sung-Ho Moon, Changjong Behavioral Tasks Evaluating Schizophrenia-like Symptoms in Animal Models: A Recent Update |
title | Behavioral Tasks Evaluating Schizophrenia-like Symptoms in Animal Models: A Recent Update |
title_full | Behavioral Tasks Evaluating Schizophrenia-like Symptoms in Animal Models: A Recent Update |
title_fullStr | Behavioral Tasks Evaluating Schizophrenia-like Symptoms in Animal Models: A Recent Update |
title_full_unstemmed | Behavioral Tasks Evaluating Schizophrenia-like Symptoms in Animal Models: A Recent Update |
title_short | Behavioral Tasks Evaluating Schizophrenia-like Symptoms in Animal Models: A Recent Update |
title_sort | behavioral tasks evaluating schizophrenia-like symptoms in animal models: a recent update |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573744/ https://www.ncbi.nlm.nih.gov/pubmed/32798374 http://dx.doi.org/10.2174/1570159X18666200814175114 |
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