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A Review of the Role of Hypoxia in Radioresistance in Cancer Therapy

Hypoxia involves neoplastic cells. Unlike normal tissue, solid tumors are composed of aberrant vasculature, leading to a hypoxic microenvironment. Hypoxia is also known to be involved in both metastasis initiation and therapy resistance. Radiotherapy is the appropriate treatment in about half of all...

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Detalles Bibliográficos
Autores principales: Boulefour, Wafa, Rowinski, Elise, Louati, Safa, Sotton, Sandrine, Wozny, Anne-Sophie, Moreno-Acosta, Pablo, Mery, Benoite, Rodriguez-Lafrasse, Claire, Magne, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573967/
https://www.ncbi.nlm.nih.gov/pubmed/34728593
http://dx.doi.org/10.12659/MSM.934116
Descripción
Sumario:Hypoxia involves neoplastic cells. Unlike normal tissue, solid tumors are composed of aberrant vasculature, leading to a hypoxic microenvironment. Hypoxia is also known to be involved in both metastasis initiation and therapy resistance. Radiotherapy is the appropriate treatment in about half of all cancers, but loco-regional control failure and a disease recurrence often occur due to clinical radioresistance. Hypoxia induces radioresistance through a number of molecular pathways, and numerous strategies have been developed to overcome this. Nevertheless, these strategies have resulted in disappointing results, including adverse effects and limited efficacy. Additional clinical studies are needed to achieve a better understanding of the complex hypoxia pathways. This review presents an update on the mechanisms of hypoxia in radioresistance in solid tumors and the potential therapeutic solutions.