IRFinder-S: a comprehensive suite to discover and explore intron retention

Accurate quantification and detection of intron retention levels require specialized software. Building on our previous software, we create a suite of tools called IRFinder-S, to analyze and explore intron retention events in multiple samples. Specifically, IRFinder-S allows a better identification...

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Detalles Bibliográficos
Autores principales: Lorenzi, Claudio, Barriere, Sylvain, Arnold, Katharina, Luco, Reini F., Oldfield, Andrew J., Ritchie, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573998/
https://www.ncbi.nlm.nih.gov/pubmed/34749764
http://dx.doi.org/10.1186/s13059-021-02515-8
Descripción
Sumario:Accurate quantification and detection of intron retention levels require specialized software. Building on our previous software, we create a suite of tools called IRFinder-S, to analyze and explore intron retention events in multiple samples. Specifically, IRFinder-S allows a better identification of true intron retention events using a convolutional neural network, allows the sharing of intron retention results between labs, integrates a dynamic database to explore and contrast available samples, and provides a tested method to detect differential levels of intron retention. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13059-021-02515-8.

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