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Arterial stiffness in children with primary hypertension is related to subclinical inflammation

INTRODUCTION: The immune system can trigger an inflammatory process leading to blood pressure elevation and arterial damage. The aim of the study was to assess the relation between subclinical inflammation and arterial damage in pediatric patients with primary hypertension (PH) and to establish the...

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Autores principales: Skrzypczyk, Piotr, Zacharzewska, Anna, Szyszka, Michał, Ofiara, Anna, Pańczyk-Tomaszewska, Malgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8574109/
https://www.ncbi.nlm.nih.gov/pubmed/34764805
http://dx.doi.org/10.5114/ceji.2021.109156
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author Skrzypczyk, Piotr
Zacharzewska, Anna
Szyszka, Michał
Ofiara, Anna
Pańczyk-Tomaszewska, Malgorzata
author_facet Skrzypczyk, Piotr
Zacharzewska, Anna
Szyszka, Michał
Ofiara, Anna
Pańczyk-Tomaszewska, Malgorzata
author_sort Skrzypczyk, Piotr
collection PubMed
description INTRODUCTION: The immune system can trigger an inflammatory process leading to blood pressure elevation and arterial damage. The aim of the study was to assess the relation between subclinical inflammation and arterial damage in pediatric patients with primary hypertension (PH) and to establish the usefulness of neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios, and mean platelet volume (MPV) as markers of arterial damage in these subjects. MATERIAL AND METHODS: In 119 children with PH (14.94 ±2.76 years) and 45 healthy children (14.91 ±2.69 years) we analyzed markers of subclinical inflammation (NLR, PLR, MPV), clinical and biochemical parameters, office blood pressure, ambulatory blood pressure monitoring (ABPM), central blood pressure, aortic pulse wave velocity (aPWV), augmentation index corrected for heart rates 75 (AIx75HR), carotid intima media thickness (cIMT), and common carotid artery stiffness (E-tracking). RESULTS: Children with PH were characterized by significantly higher neutrophil (3.9 ±1.7 vs. 3.0 ±1.0 [1000/µl], p < 0.001) and platelet counts (271.9 ±62.3 vs. 250.3 ±60.3 [1000/µl], p = 0.047), NLR (1.9 ±1.5 vs. 1.3 ±0.4, p = 0.010), PLR (131.4 ±41.9 vs. 114.7 ±37.6, p = 0.020), aPWV (5.36 ±0.88 vs. 4.88 ±0.92 m/s, p = 0.004), and cIMT (0.46 ±0.07 vs. 0.43 ±0.07 mm, p = 0.002) compared to healthy children. In PH children NLR correlated positively (p < 0.05) with: systolic, diastolic and mean blood pressure in ABPM (r = 0.243, r = 0.216, r = 0.251), aPWV [m/s] (r = 0.241), aPWV Z-score (r = 0.204), and common carotid artery PWVbeta [m/s] (r = 0.202). CONCLUSIONS: There is a link between arterial stiffness and subclinical inflammation in pediatric patients with primary hypertension. Neutrophil-to-lymphocyte ratio may serve as a promising marker of arterial stiffness in pediatric patients affected by primary hypertension.
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spelling pubmed-85741092021-11-10 Arterial stiffness in children with primary hypertension is related to subclinical inflammation Skrzypczyk, Piotr Zacharzewska, Anna Szyszka, Michał Ofiara, Anna Pańczyk-Tomaszewska, Malgorzata Cent Eur J Immunol Clinical Immunology INTRODUCTION: The immune system can trigger an inflammatory process leading to blood pressure elevation and arterial damage. The aim of the study was to assess the relation between subclinical inflammation and arterial damage in pediatric patients with primary hypertension (PH) and to establish the usefulness of neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios, and mean platelet volume (MPV) as markers of arterial damage in these subjects. MATERIAL AND METHODS: In 119 children with PH (14.94 ±2.76 years) and 45 healthy children (14.91 ±2.69 years) we analyzed markers of subclinical inflammation (NLR, PLR, MPV), clinical and biochemical parameters, office blood pressure, ambulatory blood pressure monitoring (ABPM), central blood pressure, aortic pulse wave velocity (aPWV), augmentation index corrected for heart rates 75 (AIx75HR), carotid intima media thickness (cIMT), and common carotid artery stiffness (E-tracking). RESULTS: Children with PH were characterized by significantly higher neutrophil (3.9 ±1.7 vs. 3.0 ±1.0 [1000/µl], p < 0.001) and platelet counts (271.9 ±62.3 vs. 250.3 ±60.3 [1000/µl], p = 0.047), NLR (1.9 ±1.5 vs. 1.3 ±0.4, p = 0.010), PLR (131.4 ±41.9 vs. 114.7 ±37.6, p = 0.020), aPWV (5.36 ±0.88 vs. 4.88 ±0.92 m/s, p = 0.004), and cIMT (0.46 ±0.07 vs. 0.43 ±0.07 mm, p = 0.002) compared to healthy children. In PH children NLR correlated positively (p < 0.05) with: systolic, diastolic and mean blood pressure in ABPM (r = 0.243, r = 0.216, r = 0.251), aPWV [m/s] (r = 0.241), aPWV Z-score (r = 0.204), and common carotid artery PWVbeta [m/s] (r = 0.202). CONCLUSIONS: There is a link between arterial stiffness and subclinical inflammation in pediatric patients with primary hypertension. Neutrophil-to-lymphocyte ratio may serve as a promising marker of arterial stiffness in pediatric patients affected by primary hypertension. Termedia Publishing House 2021-10-06 2021 /pmc/articles/PMC8574109/ /pubmed/34764805 http://dx.doi.org/10.5114/ceji.2021.109156 Text en Copyright © 2021 Termedia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) )
spellingShingle Clinical Immunology
Skrzypczyk, Piotr
Zacharzewska, Anna
Szyszka, Michał
Ofiara, Anna
Pańczyk-Tomaszewska, Malgorzata
Arterial stiffness in children with primary hypertension is related to subclinical inflammation
title Arterial stiffness in children with primary hypertension is related to subclinical inflammation
title_full Arterial stiffness in children with primary hypertension is related to subclinical inflammation
title_fullStr Arterial stiffness in children with primary hypertension is related to subclinical inflammation
title_full_unstemmed Arterial stiffness in children with primary hypertension is related to subclinical inflammation
title_short Arterial stiffness in children with primary hypertension is related to subclinical inflammation
title_sort arterial stiffness in children with primary hypertension is related to subclinical inflammation
topic Clinical Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8574109/
https://www.ncbi.nlm.nih.gov/pubmed/34764805
http://dx.doi.org/10.5114/ceji.2021.109156
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