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Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population
Gut microbiota dysbiosis has been associated with many neurological diseases. However, how microbiota composition and metabolism relate to neurocognitive impairment (NCI) in HIV-infected individuals is largely unknown. In this study, a total of 102 HIV infected participants were classified into two...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8574817/ https://www.ncbi.nlm.nih.gov/pubmed/34760715 http://dx.doi.org/10.3389/fcimb.2021.723840 |
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author | Dong, Ruihua Lin, Haijiang Chen, Xiaoxiao Shi, Ruizi Yuan, Shiying Li, Jing Zhu, Bowen Xu, Xiaohui Shen, Weiwei Wang, Keran Shu, Xiao-Ou Ding, Ding He, Na |
author_facet | Dong, Ruihua Lin, Haijiang Chen, Xiaoxiao Shi, Ruizi Yuan, Shiying Li, Jing Zhu, Bowen Xu, Xiaohui Shen, Weiwei Wang, Keran Shu, Xiao-Ou Ding, Ding He, Na |
author_sort | Dong, Ruihua |
collection | PubMed |
description | Gut microbiota dysbiosis has been associated with many neurological diseases. However, how microbiota composition and metabolism relate to neurocognitive impairment (NCI) in HIV-infected individuals is largely unknown. In this study, a total of 102 HIV infected participants were classified into two groups—those with NCI and those without—using the global deficit score (GDS). Fecal samples were collected from the participants for 16S rRNA gene sequencing and untargeted metabolomics. The plasma level of 25 hydroxy-vitamin D (25(OH)D) was also evaluated. Although α-diversity and β-diversity were comparable, the HIV patients with NCI were significantly different from those without NCI in terms of abundance of several gut microbiota. The decreased abundance of butyrate-producing bacteria (BPB) and increased abundance of Klebsiella were related with NCI and carotid intima-media thickness (CIMT). Significant differences in fecal metabolites were also found between individuals with versus without NCI, including increased bile acids and bioactive lipids, decreased vitamin D, terpenoids, and resolvin D1 in the NCI group. Furthermore, the perturbed metabolic profile was closely related to BPB and Klebsiella. In addition, a low level of vitamin D was associated with NCI and CIMT. Both fecal and plasma vitamin D were positively correlated with BPB. Our results show that BPB and Klebsiella and the associated metabolites are associated with NCI in people with HIV. In addition, vitamin D, both in feces and blood, was associated with NCI and BPB, suggesting a protective effect of vitamin D on NCI. |
format | Online Article Text |
id | pubmed-8574817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85748172021-11-09 Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population Dong, Ruihua Lin, Haijiang Chen, Xiaoxiao Shi, Ruizi Yuan, Shiying Li, Jing Zhu, Bowen Xu, Xiaohui Shen, Weiwei Wang, Keran Shu, Xiao-Ou Ding, Ding He, Na Front Cell Infect Microbiol Cellular and Infection Microbiology Gut microbiota dysbiosis has been associated with many neurological diseases. However, how microbiota composition and metabolism relate to neurocognitive impairment (NCI) in HIV-infected individuals is largely unknown. In this study, a total of 102 HIV infected participants were classified into two groups—those with NCI and those without—using the global deficit score (GDS). Fecal samples were collected from the participants for 16S rRNA gene sequencing and untargeted metabolomics. The plasma level of 25 hydroxy-vitamin D (25(OH)D) was also evaluated. Although α-diversity and β-diversity were comparable, the HIV patients with NCI were significantly different from those without NCI in terms of abundance of several gut microbiota. The decreased abundance of butyrate-producing bacteria (BPB) and increased abundance of Klebsiella were related with NCI and carotid intima-media thickness (CIMT). Significant differences in fecal metabolites were also found between individuals with versus without NCI, including increased bile acids and bioactive lipids, decreased vitamin D, terpenoids, and resolvin D1 in the NCI group. Furthermore, the perturbed metabolic profile was closely related to BPB and Klebsiella. In addition, a low level of vitamin D was associated with NCI and CIMT. Both fecal and plasma vitamin D were positively correlated with BPB. Our results show that BPB and Klebsiella and the associated metabolites are associated with NCI in people with HIV. In addition, vitamin D, both in feces and blood, was associated with NCI and BPB, suggesting a protective effect of vitamin D on NCI. Frontiers Media S.A. 2021-10-25 /pmc/articles/PMC8574817/ /pubmed/34760715 http://dx.doi.org/10.3389/fcimb.2021.723840 Text en Copyright © 2021 Dong, Lin, Chen, Shi, Yuan, Li, Zhu, Xu, Shen, Wang, Shu, Ding and He https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Dong, Ruihua Lin, Haijiang Chen, Xiaoxiao Shi, Ruizi Yuan, Shiying Li, Jing Zhu, Bowen Xu, Xiaohui Shen, Weiwei Wang, Keran Shu, Xiao-Ou Ding, Ding He, Na Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population |
title | Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population |
title_full | Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population |
title_fullStr | Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population |
title_full_unstemmed | Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population |
title_short | Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population |
title_sort | gut microbiota and fecal metabolites associated with neurocognitive impairment in hiv-infected population |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8574817/ https://www.ncbi.nlm.nih.gov/pubmed/34760715 http://dx.doi.org/10.3389/fcimb.2021.723840 |
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