Cargando…

Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population

Gut microbiota dysbiosis has been associated with many neurological diseases. However, how microbiota composition and metabolism relate to neurocognitive impairment (NCI) in HIV-infected individuals is largely unknown. In this study, a total of 102 HIV infected participants were classified into two...

Descripción completa

Detalles Bibliográficos
Autores principales: Dong, Ruihua, Lin, Haijiang, Chen, Xiaoxiao, Shi, Ruizi, Yuan, Shiying, Li, Jing, Zhu, Bowen, Xu, Xiaohui, Shen, Weiwei, Wang, Keran, Shu, Xiao-Ou, Ding, Ding, He, Na
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8574817/
https://www.ncbi.nlm.nih.gov/pubmed/34760715
http://dx.doi.org/10.3389/fcimb.2021.723840
_version_ 1784595585405288448
author Dong, Ruihua
Lin, Haijiang
Chen, Xiaoxiao
Shi, Ruizi
Yuan, Shiying
Li, Jing
Zhu, Bowen
Xu, Xiaohui
Shen, Weiwei
Wang, Keran
Shu, Xiao-Ou
Ding, Ding
He, Na
author_facet Dong, Ruihua
Lin, Haijiang
Chen, Xiaoxiao
Shi, Ruizi
Yuan, Shiying
Li, Jing
Zhu, Bowen
Xu, Xiaohui
Shen, Weiwei
Wang, Keran
Shu, Xiao-Ou
Ding, Ding
He, Na
author_sort Dong, Ruihua
collection PubMed
description Gut microbiota dysbiosis has been associated with many neurological diseases. However, how microbiota composition and metabolism relate to neurocognitive impairment (NCI) in HIV-infected individuals is largely unknown. In this study, a total of 102 HIV infected participants were classified into two groups—those with NCI and those without—using the global deficit score (GDS). Fecal samples were collected from the participants for 16S rRNA gene sequencing and untargeted metabolomics. The plasma level of 25 hydroxy-vitamin D (25(OH)D) was also evaluated. Although α-diversity and β-diversity were comparable, the HIV patients with NCI were significantly different from those without NCI in terms of abundance of several gut microbiota. The decreased abundance of butyrate-producing bacteria (BPB) and increased abundance of Klebsiella were related with NCI and carotid intima-media thickness (CIMT). Significant differences in fecal metabolites were also found between individuals with versus without NCI, including increased bile acids and bioactive lipids, decreased vitamin D, terpenoids, and resolvin D1 in the NCI group. Furthermore, the perturbed metabolic profile was closely related to BPB and Klebsiella. In addition, a low level of vitamin D was associated with NCI and CIMT. Both fecal and plasma vitamin D were positively correlated with BPB. Our results show that BPB and Klebsiella and the associated metabolites are associated with NCI in people with HIV. In addition, vitamin D, both in feces and blood, was associated with NCI and BPB, suggesting a protective effect of vitamin D on NCI.
format Online
Article
Text
id pubmed-8574817
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-85748172021-11-09 Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population Dong, Ruihua Lin, Haijiang Chen, Xiaoxiao Shi, Ruizi Yuan, Shiying Li, Jing Zhu, Bowen Xu, Xiaohui Shen, Weiwei Wang, Keran Shu, Xiao-Ou Ding, Ding He, Na Front Cell Infect Microbiol Cellular and Infection Microbiology Gut microbiota dysbiosis has been associated with many neurological diseases. However, how microbiota composition and metabolism relate to neurocognitive impairment (NCI) in HIV-infected individuals is largely unknown. In this study, a total of 102 HIV infected participants were classified into two groups—those with NCI and those without—using the global deficit score (GDS). Fecal samples were collected from the participants for 16S rRNA gene sequencing and untargeted metabolomics. The plasma level of 25 hydroxy-vitamin D (25(OH)D) was also evaluated. Although α-diversity and β-diversity were comparable, the HIV patients with NCI were significantly different from those without NCI in terms of abundance of several gut microbiota. The decreased abundance of butyrate-producing bacteria (BPB) and increased abundance of Klebsiella were related with NCI and carotid intima-media thickness (CIMT). Significant differences in fecal metabolites were also found between individuals with versus without NCI, including increased bile acids and bioactive lipids, decreased vitamin D, terpenoids, and resolvin D1 in the NCI group. Furthermore, the perturbed metabolic profile was closely related to BPB and Klebsiella. In addition, a low level of vitamin D was associated with NCI and CIMT. Both fecal and plasma vitamin D were positively correlated with BPB. Our results show that BPB and Klebsiella and the associated metabolites are associated with NCI in people with HIV. In addition, vitamin D, both in feces and blood, was associated with NCI and BPB, suggesting a protective effect of vitamin D on NCI. Frontiers Media S.A. 2021-10-25 /pmc/articles/PMC8574817/ /pubmed/34760715 http://dx.doi.org/10.3389/fcimb.2021.723840 Text en Copyright © 2021 Dong, Lin, Chen, Shi, Yuan, Li, Zhu, Xu, Shen, Wang, Shu, Ding and He https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Dong, Ruihua
Lin, Haijiang
Chen, Xiaoxiao
Shi, Ruizi
Yuan, Shiying
Li, Jing
Zhu, Bowen
Xu, Xiaohui
Shen, Weiwei
Wang, Keran
Shu, Xiao-Ou
Ding, Ding
He, Na
Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population
title Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population
title_full Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population
title_fullStr Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population
title_full_unstemmed Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population
title_short Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population
title_sort gut microbiota and fecal metabolites associated with neurocognitive impairment in hiv-infected population
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8574817/
https://www.ncbi.nlm.nih.gov/pubmed/34760715
http://dx.doi.org/10.3389/fcimb.2021.723840
work_keys_str_mv AT dongruihua gutmicrobiotaandfecalmetabolitesassociatedwithneurocognitiveimpairmentinhivinfectedpopulation
AT linhaijiang gutmicrobiotaandfecalmetabolitesassociatedwithneurocognitiveimpairmentinhivinfectedpopulation
AT chenxiaoxiao gutmicrobiotaandfecalmetabolitesassociatedwithneurocognitiveimpairmentinhivinfectedpopulation
AT shiruizi gutmicrobiotaandfecalmetabolitesassociatedwithneurocognitiveimpairmentinhivinfectedpopulation
AT yuanshiying gutmicrobiotaandfecalmetabolitesassociatedwithneurocognitiveimpairmentinhivinfectedpopulation
AT lijing gutmicrobiotaandfecalmetabolitesassociatedwithneurocognitiveimpairmentinhivinfectedpopulation
AT zhubowen gutmicrobiotaandfecalmetabolitesassociatedwithneurocognitiveimpairmentinhivinfectedpopulation
AT xuxiaohui gutmicrobiotaandfecalmetabolitesassociatedwithneurocognitiveimpairmentinhivinfectedpopulation
AT shenweiwei gutmicrobiotaandfecalmetabolitesassociatedwithneurocognitiveimpairmentinhivinfectedpopulation
AT wangkeran gutmicrobiotaandfecalmetabolitesassociatedwithneurocognitiveimpairmentinhivinfectedpopulation
AT shuxiaoou gutmicrobiotaandfecalmetabolitesassociatedwithneurocognitiveimpairmentinhivinfectedpopulation
AT dingding gutmicrobiotaandfecalmetabolitesassociatedwithneurocognitiveimpairmentinhivinfectedpopulation
AT hena gutmicrobiotaandfecalmetabolitesassociatedwithneurocognitiveimpairmentinhivinfectedpopulation