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Rapid and Sensitive Diagnosis of Drug-Resistant FLT3-F691L Mutation by CRISPR Detection

Sensitive and efficient detection of drug-resistant mutations is essential in cancer precision medicine. In treating acute myeloid leukemia (AML), FLT3 gene F691L mutation shows universal resistance to all currently available FLT3 inhibitors. However, there is no particular detection method for FLT3...

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Detalles Bibliográficos
Autores principales:	Liu, Yin, Chen, Yanling, Huang, Shisheng, Ma, Xiaodong, Huang, Xingxu, Wang, Xinjie, Zhou, Fuling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8574994/ https://www.ncbi.nlm.nih.gov/pubmed/34760927 http://dx.doi.org/10.3389/fmolb.2021.753276

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