Suppressing Kv1.3 Ion Channel Activity with a Novel Small Molecule Inhibitor Ameliorates Inflammation in a Humanised Mouse Model of Ulcerative Colitis

BACKGROUND AND AIMS: The potassium channel Kv1.3 is a potentially attractive therapeutic target in T cell-mediated inflammatory diseases, as the activity of antigen-activated T cells is selectively impeded by Kv1.3 inhibition. In this study, we examined Kv1.3 as a potential therapeutic intervention...

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Detalles Bibliográficos
Autores principales: Unterweger, Anna-Lena, Jensen, Morten Ø, Giordanetto, Fabrizio, Jogini, Vishwanath, Rüschher, Alena, Seuß, Marietta, Winkelmann, Paula, Koletzko, Leandra, Shaw, David E, Siebeck, Matthias, Gropp, Roswitha, Beigel, Florian, Aszodi, Attila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575044/
https://www.ncbi.nlm.nih.gov/pubmed/33891001
http://dx.doi.org/10.1093/ecco-jcc/jjab078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575044/
https://www.ncbi.nlm.nih.gov/pubmed/33891001
http://dx.doi.org/10.1093/ecco-jcc/jjab078

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