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Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain

Mutations in TREM2, a receptor expressed by microglia in the brain, are associated with an increased risk of neurodegeneration, including Alzheimer's disease. Numerous studies support a role for TREM2 in sensing damaging stimuli and triggering signaling cascades necessary for neuroprotection. D...

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Detalles Bibliográficos
Autores principales:	Szykowska, Aleksandra, Chen, Yu, Smith, Thomas B., Preger, Charlotta, Yang, Jingjing, Qian, Dongming, Mukhopadhyay, Shubhashish M., Wigren, Edvard, Neame, Stephen J., Gräslund, Susanne, Persson, Helena, Atkinson, Peter J., Di Daniel, Elena, Mead, Emma, Wang, John, Davis, John B., Burgess-Brown, Nicola A., Bullock, Alex N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575122/ https://www.ncbi.nlm.nih.gov/pubmed/34233201 http://dx.doi.org/10.1016/j.str.2021.06.010

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