Germinal centre-driven maturation of B cell response to SARS-CoV-2 vaccination

Germinal centres (GC) are lymphoid structures where vaccine-responding B cells acquire affinity-enhancing somatic hypermutations (SHM), with surviving clones differentiating into memory B cells (MBCs) and long-lived bone marrow plasma cells (BMPCs)(1–4). Induction of the latter is a hallmark of dura...

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Detalles Bibliográficos
Autores principales: Kim, Wooseob, Zhou, Julian Q., Sturtz, Alexandria J., Horvath, Stephen C., Schmitz, Aaron J., Lei, Tingting, Kalaidina, Elizaveta, Thapa, Mahima, Alsoussi, Wafaa B., Haile, Alem, Klebert, Michael K., Suessen, Teresa, Parra-Rodriguez, Luis, Mudd, Philip A., Middleton, William D., Teefey, Sharlene A., Pusic, Iskra, O’Halloran, Jane A., Presti, Rachel M., Turner, Jackson S., Ellebedy, Ali H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575138/
https://www.ncbi.nlm.nih.gov/pubmed/34751268
http://dx.doi.org/10.1101/2021.10.31.466651

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