Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19

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Type I interferon (IFN) is critical in our defense against viral infections. Increased type I IFN pathway activation is a genetic risk factor for systemic lupus erythematosus (SLE), and a number of common risk alleles contribute to the high IFN trait. We hypothesized that these common gain-of-functi...

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Detalles Bibliográficos
Autores principales: Nln, Ilona, Fernandez-Ruiz, Ruth, Wampler Muskardin, Theresa L., Paredes, Jacqueline L., Blazer, Ashira D., Tuminello, Stephanie, Attur, Mukundan, Iturrate, Eduardo, Petrilli, Christopher M., Abramson, Steven B., Chakravarti, Aravinda, Niewold, Timothy B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575145/
https://www.ncbi.nlm.nih.gov/pubmed/34751274
http://dx.doi.org/10.1101/2021.11.01.21265766
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