Hypotonic-hyporesponsive Episodes After Diphtheria, Tetanus and Acellular Pertussis Vaccination

Hypotonic-hyporesponsive episode (HHE) after whole cell pertussis vaccination is a known adverse event. Less is known about the risk of HHE after administration of acellular pertussis vaccines. METHODS: Using parental interviews, this study actively surveyed for HHE among infants after doses 1 and 2...

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Detalles Bibliográficos
Autores principales: Hansen, John, Decker, Michael D., Lewis, Edwin, Fireman, Bruce, Pool, Vitali, Greenberg, David P., Johnson, David R., Black, Steven, Klein, Nicola P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Vaccine Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575166/
https://www.ncbi.nlm.nih.gov/pubmed/34420008
http://dx.doi.org/10.1097/INF.0000000000003308
Descripción
Sumario:Hypotonic-hyporesponsive episode (HHE) after whole cell pertussis vaccination is a known adverse event. Less is known about the risk of HHE after administration of acellular pertussis vaccines. METHODS: Using parental interviews, this study actively surveyed for HHE among infants after doses 1 and 2 of acellular pertussis vaccine. RESULTS: We interviewed the parents of 52,531 infants. HHE was reported at a rate of 22.8 per 100,000 doses (95% CI: 11.8–39.9) of acellular pertussis vaccine, approximately 45 episodes per 100,000 children. CONCLUSIONS: These rates are lower than HHE rates reported after whole cell pertussis vaccines and within the range of HHE rates reported in other studies of acellular pertussis vaccines.

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