Hypotonic-hyporesponsive Episodes After Diphtheria, Tetanus and Acellular Pertussis Vaccination

Hypotonic-hyporesponsive episode (HHE) after whole cell pertussis vaccination is a known adverse event. Less is known about the risk of HHE after administration of acellular pertussis vaccines. METHODS: Using parental interviews, this study actively surveyed for HHE among infants after doses 1 and 2...

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Autores principales: Hansen, John, Decker, Michael D., Lewis, Edwin, Fireman, Bruce, Pool, Vitali, Greenberg, David P., Johnson, David R., Black, Steven, Klein, Nicola P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Vaccine Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575166/
https://www.ncbi.nlm.nih.gov/pubmed/34420008
http://dx.doi.org/10.1097/INF.0000000000003308
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author Hansen, John
Decker, Michael D.
Lewis, Edwin
Fireman, Bruce
Pool, Vitali
Greenberg, David P.
Johnson, David R.
Black, Steven
Klein, Nicola P.
author_facet Hansen, John
Decker, Michael D.
Lewis, Edwin
Fireman, Bruce
Pool, Vitali
Greenberg, David P.
Johnson, David R.
Black, Steven
Klein, Nicola P.
author_sort Hansen, John
collection PubMed
description Hypotonic-hyporesponsive episode (HHE) after whole cell pertussis vaccination is a known adverse event. Less is known about the risk of HHE after administration of acellular pertussis vaccines. METHODS: Using parental interviews, this study actively surveyed for HHE among infants after doses 1 and 2 of acellular pertussis vaccine. RESULTS: We interviewed the parents of 52,531 infants. HHE was reported at a rate of 22.8 per 100,000 doses (95% CI: 11.8–39.9) of acellular pertussis vaccine, approximately 45 episodes per 100,000 children. CONCLUSIONS: These rates are lower than HHE rates reported after whole cell pertussis vaccines and within the range of HHE rates reported in other studies of acellular pertussis vaccines.
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spelling pubmed-85751662021-11-12 Hypotonic-hyporesponsive Episodes After Diphtheria, Tetanus and Acellular Pertussis Vaccination Hansen, John Decker, Michael D. Lewis, Edwin Fireman, Bruce Pool, Vitali Greenberg, David P. Johnson, David R. Black, Steven Klein, Nicola P. Pediatr Infect Dis J Vaccine Reports Hypotonic-hyporesponsive episode (HHE) after whole cell pertussis vaccination is a known adverse event. Less is known about the risk of HHE after administration of acellular pertussis vaccines. METHODS: Using parental interviews, this study actively surveyed for HHE among infants after doses 1 and 2 of acellular pertussis vaccine. RESULTS: We interviewed the parents of 52,531 infants. HHE was reported at a rate of 22.8 per 100,000 doses (95% CI: 11.8–39.9) of acellular pertussis vaccine, approximately 45 episodes per 100,000 children. CONCLUSIONS: These rates are lower than HHE rates reported after whole cell pertussis vaccines and within the range of HHE rates reported in other studies of acellular pertussis vaccines. Lippincott Williams & Wilkins 2021-08-20 2021-12 /pmc/articles/PMC8575166/ /pubmed/34420008 http://dx.doi.org/10.1097/INF.0000000000003308 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Vaccine Reports
Hansen, John
Decker, Michael D.
Lewis, Edwin
Fireman, Bruce
Pool, Vitali
Greenberg, David P.
Johnson, David R.
Black, Steven
Klein, Nicola P.
Hypotonic-hyporesponsive Episodes After Diphtheria, Tetanus and Acellular Pertussis Vaccination
title Hypotonic-hyporesponsive Episodes After Diphtheria, Tetanus and Acellular Pertussis Vaccination
title_full Hypotonic-hyporesponsive Episodes After Diphtheria, Tetanus and Acellular Pertussis Vaccination
title_fullStr Hypotonic-hyporesponsive Episodes After Diphtheria, Tetanus and Acellular Pertussis Vaccination
title_full_unstemmed Hypotonic-hyporesponsive Episodes After Diphtheria, Tetanus and Acellular Pertussis Vaccination
title_short Hypotonic-hyporesponsive Episodes After Diphtheria, Tetanus and Acellular Pertussis Vaccination
title_sort hypotonic-hyporesponsive episodes after diphtheria, tetanus and acellular pertussis vaccination
topic Vaccine Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575166/
https://www.ncbi.nlm.nih.gov/pubmed/34420008
http://dx.doi.org/10.1097/INF.0000000000003308
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