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Unbiased high-content screening reveals Aβ- and tau-independent synaptotoxic activities in human brain homogenates from Alzheimer’s patients and high-pathology controls

Alzheimer’s disease (AD) is tightly correlated with synapse loss in vulnerable brain regions. It is assumed that specific molecular entities such as Aβ and tau cause synapse loss in AD, yet unbiased screens for synaptotoxic activities have not been performed. Here, we performed size exclusion chroma...

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Detalles Bibliográficos
Autores principales:	Jiang, Hao, Esparza, Thomas J., Kummer, Terrance T., Brody, David L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575250/ https://www.ncbi.nlm.nih.gov/pubmed/34748596 http://dx.doi.org/10.1371/journal.pone.0259335

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