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Hydroxynonenal causes Langerhans cell degeneration in the pancreas of Japanese macaque monkeys
BACKGROUND: For their functions of insulin biosynthesis and glucose- and fatty acid- mediated insulin secretion, Langerhans β-cells require an intracellular milieu rich in oxygen. This requirement makes β-cells, with their constitutively low antioxidative defense, susceptible to the oxidative stress...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575276/ https://www.ncbi.nlm.nih.gov/pubmed/34748564 http://dx.doi.org/10.1371/journal.pone.0245702 |