Cargando…
Characteristics of upper urinary tract urothelial carcinoma in the context of bladder cancer: a narrative review
Urothelial carcinomas (UC) arise from the urothelium that covers the proximal urethra, urinary bladder, and the upper urinary tract. In daily routine and clinical trials UC originating from different locations are often treated and investigated in the same manner. However, differences between the tw...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575564/ https://www.ncbi.nlm.nih.gov/pubmed/34804846 http://dx.doi.org/10.21037/tau-20-1472 |
_version_ | 1784595698971312128 |
---|---|
author | Giudici, Nicola Bonne, Fieke Blarer, Jennifer Minoli, Martina Krentel, Friedemann Seiler, Roland |
author_facet | Giudici, Nicola Bonne, Fieke Blarer, Jennifer Minoli, Martina Krentel, Friedemann Seiler, Roland |
author_sort | Giudici, Nicola |
collection | PubMed |
description | Urothelial carcinomas (UC) arise from the urothelium that covers the proximal urethra, urinary bladder, and the upper urinary tract. In daily routine and clinical trials UC originating from different locations are often treated and investigated in the same manner. However, differences between the two locations seem to be apparent and may question in handling them as a single oncologic entity. In this review we discuss similarities and differences between bladder and upper urinary tract UC and consider their potential impact on treatment strategies. Despite similarities of UC in the bladder (BC) and the upper urinary tract (UTUC), clinicopathologic and molecular differences may question to generally assemble both as a single tumor entity. Treatment standards for UTUC are often adopted from BC. However, a specific investigation in the former may still be meaningful as shown by the example of adjuvant cisplatin based chemotherapy. In conclusion, future investigations should prioritize the understanding of the tumor biology of both BC and UTUC. This may reveal which UTUC can be treated according to treatment standards of BC and in which cases, a separate approach may be more appropriate. |
format | Online Article Text |
id | pubmed-8575564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-85755642021-11-18 Characteristics of upper urinary tract urothelial carcinoma in the context of bladder cancer: a narrative review Giudici, Nicola Bonne, Fieke Blarer, Jennifer Minoli, Martina Krentel, Friedemann Seiler, Roland Transl Androl Urol Review Article on Management of Advanced Genitourinary Malignancies Urothelial carcinomas (UC) arise from the urothelium that covers the proximal urethra, urinary bladder, and the upper urinary tract. In daily routine and clinical trials UC originating from different locations are often treated and investigated in the same manner. However, differences between the two locations seem to be apparent and may question in handling them as a single oncologic entity. In this review we discuss similarities and differences between bladder and upper urinary tract UC and consider their potential impact on treatment strategies. Despite similarities of UC in the bladder (BC) and the upper urinary tract (UTUC), clinicopathologic and molecular differences may question to generally assemble both as a single tumor entity. Treatment standards for UTUC are often adopted from BC. However, a specific investigation in the former may still be meaningful as shown by the example of adjuvant cisplatin based chemotherapy. In conclusion, future investigations should prioritize the understanding of the tumor biology of both BC and UTUC. This may reveal which UTUC can be treated according to treatment standards of BC and in which cases, a separate approach may be more appropriate. AME Publishing Company 2021-10 /pmc/articles/PMC8575564/ /pubmed/34804846 http://dx.doi.org/10.21037/tau-20-1472 Text en 2021 Translational Andrology and Urology. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Review Article on Management of Advanced Genitourinary Malignancies Giudici, Nicola Bonne, Fieke Blarer, Jennifer Minoli, Martina Krentel, Friedemann Seiler, Roland Characteristics of upper urinary tract urothelial carcinoma in the context of bladder cancer: a narrative review |
title | Characteristics of upper urinary tract urothelial carcinoma in the context of bladder cancer: a narrative review |
title_full | Characteristics of upper urinary tract urothelial carcinoma in the context of bladder cancer: a narrative review |
title_fullStr | Characteristics of upper urinary tract urothelial carcinoma in the context of bladder cancer: a narrative review |
title_full_unstemmed | Characteristics of upper urinary tract urothelial carcinoma in the context of bladder cancer: a narrative review |
title_short | Characteristics of upper urinary tract urothelial carcinoma in the context of bladder cancer: a narrative review |
title_sort | characteristics of upper urinary tract urothelial carcinoma in the context of bladder cancer: a narrative review |
topic | Review Article on Management of Advanced Genitourinary Malignancies |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575564/ https://www.ncbi.nlm.nih.gov/pubmed/34804846 http://dx.doi.org/10.21037/tau-20-1472 |
work_keys_str_mv | AT giudicinicola characteristicsofupperurinarytracturothelialcarcinomainthecontextofbladdercanceranarrativereview AT bonnefieke characteristicsofupperurinarytracturothelialcarcinomainthecontextofbladdercanceranarrativereview AT blarerjennifer characteristicsofupperurinarytracturothelialcarcinomainthecontextofbladdercanceranarrativereview AT minolimartina characteristicsofupperurinarytracturothelialcarcinomainthecontextofbladdercanceranarrativereview AT krentelfriedemann characteristicsofupperurinarytracturothelialcarcinomainthecontextofbladdercanceranarrativereview AT seilerroland characteristicsofupperurinarytracturothelialcarcinomainthecontextofbladdercanceranarrativereview |