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Olive Leaf Extract Supplementation Combined with Calorie-Restricted Diet on Reducing Body Weight and Fat Mass in Obese Women: Result of a Randomized Control Trial

The present trial aims to evaluate a supplementation of the olive leaf extract (OLE) in adjunct with a weight loss diet on anthropometric indices, glycemic indices, lipid profile, as well as the level of adipokines, and free fatty acid in obese women. We carried out an 8-week randomized, placebo-con...

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Autores principales: Haidari, Fatemeh, Shayesteh, Forough, Mohammad-shahi, Majid, Jalali, Mohammad-Taha, Ahmadi-Angali, Kambiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Clinical Nutrition 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575641/
https://www.ncbi.nlm.nih.gov/pubmed/34796136
http://dx.doi.org/10.7762/cnr.2021.10.4.314
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author Haidari, Fatemeh
Shayesteh, Forough
Mohammad-shahi, Majid
Jalali, Mohammad-Taha
Ahmadi-Angali, Kambiz
author_facet Haidari, Fatemeh
Shayesteh, Forough
Mohammad-shahi, Majid
Jalali, Mohammad-Taha
Ahmadi-Angali, Kambiz
author_sort Haidari, Fatemeh
collection PubMed
description The present trial aims to evaluate a supplementation of the olive leaf extract (OLE) in adjunct with a weight loss diet on anthropometric indices, glycemic indices, lipid profile, as well as the level of adipokines, and free fatty acid in obese women. We carried out an 8-week randomized, placebo-controlled, double-blind, parallel-group, clinical trial. The participants were randomly stratified according to age and they were assigned to one of the two study groups: Standard weight loss diet (estimated daily energy requirements minus 500 kcal) + OLE supplementation (n = 35) in intervention group or Standard weight loss diet (estimated daily energy requirements minus 500 kcal) + placebo (n = 35) in placebo group. The study groups were homogeneous regarding the baseline age, height, weight, body mass index (BMI), waist circumferences, married status, and physical activity levels (p > 0.05). The results of analysis of covariance presented significant decreases in BMI, fat mass, and body weight in the OLE group compared to those in the placebo group (p < 0.05). At the end of the study, the serum levels of fasting blood sugar, insulin, low-density lipoprotein cholesterol, total cholesterol, leptin, fatty free acid, and homeostasis model assessment–insulin resistance significantly decreased, and serum levels of high-density lipoprotein cholesterol and adiponectin elevated in the intervention group (p < 0.05). Based on results it seems that the addition of OLE to a hypocaloric diet for 8-week compared with a hypocaloric diet alone may be more effective in modifying obesity and metabolic risk factors. TRIAL REGISTRATION: Iranian Registry of Clinical Trials Identifier: IRCT20190129042552N2
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spelling pubmed-85756412021-11-17 Olive Leaf Extract Supplementation Combined with Calorie-Restricted Diet on Reducing Body Weight and Fat Mass in Obese Women: Result of a Randomized Control Trial Haidari, Fatemeh Shayesteh, Forough Mohammad-shahi, Majid Jalali, Mohammad-Taha Ahmadi-Angali, Kambiz Clin Nutr Res Original Article The present trial aims to evaluate a supplementation of the olive leaf extract (OLE) in adjunct with a weight loss diet on anthropometric indices, glycemic indices, lipid profile, as well as the level of adipokines, and free fatty acid in obese women. We carried out an 8-week randomized, placebo-controlled, double-blind, parallel-group, clinical trial. The participants were randomly stratified according to age and they were assigned to one of the two study groups: Standard weight loss diet (estimated daily energy requirements minus 500 kcal) + OLE supplementation (n = 35) in intervention group or Standard weight loss diet (estimated daily energy requirements minus 500 kcal) + placebo (n = 35) in placebo group. The study groups were homogeneous regarding the baseline age, height, weight, body mass index (BMI), waist circumferences, married status, and physical activity levels (p > 0.05). The results of analysis of covariance presented significant decreases in BMI, fat mass, and body weight in the OLE group compared to those in the placebo group (p < 0.05). At the end of the study, the serum levels of fasting blood sugar, insulin, low-density lipoprotein cholesterol, total cholesterol, leptin, fatty free acid, and homeostasis model assessment–insulin resistance significantly decreased, and serum levels of high-density lipoprotein cholesterol and adiponectin elevated in the intervention group (p < 0.05). Based on results it seems that the addition of OLE to a hypocaloric diet for 8-week compared with a hypocaloric diet alone may be more effective in modifying obesity and metabolic risk factors. TRIAL REGISTRATION: Iranian Registry of Clinical Trials Identifier: IRCT20190129042552N2 Korean Society of Clinical Nutrition 2021-10-31 /pmc/articles/PMC8575641/ /pubmed/34796136 http://dx.doi.org/10.7762/cnr.2021.10.4.314 Text en Copyright © 2021. The Korean Society of Clinical Nutrition https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Haidari, Fatemeh
Shayesteh, Forough
Mohammad-shahi, Majid
Jalali, Mohammad-Taha
Ahmadi-Angali, Kambiz
Olive Leaf Extract Supplementation Combined with Calorie-Restricted Diet on Reducing Body Weight and Fat Mass in Obese Women: Result of a Randomized Control Trial
title Olive Leaf Extract Supplementation Combined with Calorie-Restricted Diet on Reducing Body Weight and Fat Mass in Obese Women: Result of a Randomized Control Trial
title_full Olive Leaf Extract Supplementation Combined with Calorie-Restricted Diet on Reducing Body Weight and Fat Mass in Obese Women: Result of a Randomized Control Trial
title_fullStr Olive Leaf Extract Supplementation Combined with Calorie-Restricted Diet on Reducing Body Weight and Fat Mass in Obese Women: Result of a Randomized Control Trial
title_full_unstemmed Olive Leaf Extract Supplementation Combined with Calorie-Restricted Diet on Reducing Body Weight and Fat Mass in Obese Women: Result of a Randomized Control Trial
title_short Olive Leaf Extract Supplementation Combined with Calorie-Restricted Diet on Reducing Body Weight and Fat Mass in Obese Women: Result of a Randomized Control Trial
title_sort olive leaf extract supplementation combined with calorie-restricted diet on reducing body weight and fat mass in obese women: result of a randomized control trial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575641/
https://www.ncbi.nlm.nih.gov/pubmed/34796136
http://dx.doi.org/10.7762/cnr.2021.10.4.314
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