Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction

The use of chimeric antigen receptor (CAR)-engineered regulatory T cells (Tregs) has emerged as a promising strategy to promote immune tolerance. However, in conventional T cells (Tconvs), CAR expression is often associated with tonic signaling, which can induce CAR-T cell dysfunction. The extent an...

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Detalles Bibliográficos
Autores principales: Lamarthée, Baptiste, Marchal, Armance, Charbonnier, Soëli, Blein, Tifanie, Leon, Juliette, Martin, Emmanuel, Rabaux, Lucas, Vogt, Katrin, Titeux, Matthias, Delville, Marianne, Vinçon, Hélène, Six, Emmanuelle, Pallet, Nicolas, Michonneau, David, Anglicheau, Dany, Legendre, Christophe, Taupin, Jean-Luc, Nemazanyy, Ivan, Sawitzki, Birgit, Latour, Sylvain, Cavazzana, Marina, André, Isabelle, Zuber, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575891/
https://www.ncbi.nlm.nih.gov/pubmed/34750385
http://dx.doi.org/10.1038/s41467-021-26844-1

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