The history and geographic distribution of a KCNQ1 atrial fibrillation risk allele

The genetic architecture of atrial fibrillation (AF) encompasses low impact, common genetic variants and high impact, rare variants. Here, we characterize a high impact AF-susceptibility allele, KCNQ1 R231H, and describe its transcontinental geographic distribution and history. Induced pluripotent s...

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Detalles Bibliográficos
Autores principales: Hateley, Shannon, Lopez-Izquierdo, Angelica, Jou, Chuanchau J., Cho, Scott, Schraiber, Joshua G., Song, Shiya, Maguire, Colin T., Torres, Natalia, Riedel, Michael, Bowles, Neil E., Arrington, Cammon B., Kennedy, Brett J., Etheridge, Susan P., Lai, Shuping, Pribble, Chase, Meyers, Lindsay, Lundahl, Derek, Byrnes, Jake, Granka, Julie M., Kauffman, Christopher A., Lemmon, Gordon, Boyden, Steven, Scott Watkins, W., Karren, Mary Anne, Knight, Stacey, Brent Muhlestein, J., Carlquist, John F., Anderson, Jeffrey L., Chahine, Kenneth G., Shah, Khushi U., Ball, Catherine A., Benjamin, Ivor J., Yandell, Mark, Tristani-Firouzi, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575962/
https://www.ncbi.nlm.nih.gov/pubmed/34750360
http://dx.doi.org/10.1038/s41467-021-26741-7

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