Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain

Ubiquitin-specific protease 8 (USP8) is a deubiquitinating enzyme involved in multiple membrane trafficking pathways. The enzyme activity is inhibited by binding to 14-3-3 proteins. Mutations in the 14-3-3-binding motif in USP8 are related to Cushing’s disease. However, the molecular basis of USP8 a...

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Detalles Bibliográficos
Autores principales: Kakihara, Keijun, Asamizu, Kengo, Moritsugu, Kei, Kubo, Masahide, Kitaguchi, Tetsuya, Endo, Akinori, Kidera, Akinori, Ikeguchi, Mitsunori, Kato, Akira, Komada, Masayuki, Fukushima, Toshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576004/
https://www.ncbi.nlm.nih.gov/pubmed/34750505
http://dx.doi.org/10.1038/s42003-021-02802-x

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