Biased activation of β(2)-AR/Gi/GRK2 signal pathway attenuated β(1)-AR sustained activation induced by β(1)-adrenergic receptor autoantibody

Heart failure is the terminal stage of many cardiac diseases, in which β(1)-adrenoceptor (β(1)-AR) autoantibody (β(1)-AA) has a causative role. By continuously activating β(1)-AR, β(1)-AA can induce cytotoxicity, leading to cardiomyocyte apoptosis and heart dysfunction. However, the mechanism underl...

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Detalles Bibliográficos
Autores principales: Chen, Hao, Cao, Ning, Wang, Li, Wu, Ye, Wei, Haojie, Li, Yuming, Zhang, Youyi, Zhang, Suli, Liu, Huirong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576015/
https://www.ncbi.nlm.nih.gov/pubmed/34750352
http://dx.doi.org/10.1038/s41420-021-00735-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576015/
https://www.ncbi.nlm.nih.gov/pubmed/34750352
http://dx.doi.org/10.1038/s41420-021-00735-2

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