Cargando…

Biased activation of β(2)-AR/Gi/GRK2 signal pathway attenuated β(1)-AR sustained activation induced by β(1)-adrenergic receptor autoantibody

Heart failure is the terminal stage of many cardiac diseases, in which β(1)-adrenoceptor (β(1)-AR) autoantibody (β(1)-AA) has a causative role. By continuously activating β(1)-AR, β(1)-AA can induce cytotoxicity, leading to cardiomyocyte apoptosis and heart dysfunction. However, the mechanism underl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Hao, Cao, Ning, Wang, Li, Wu, Ye, Wei, Haojie, Li, Yuming, Zhang, Youyi, Zhang, Suli, Liu, Huirong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576015/ https://www.ncbi.nlm.nih.gov/pubmed/34750352 http://dx.doi.org/10.1038/s41420-021-00735-2

Ejemplares similares

Gi-protein-coupled β (1)-adrenergic receptor: re-understanding the selectivity of β (1)-adrenergic receptor to G protein : Gi-protein-coupled β (1)-adrenergic receptor
por: Chen, Hao, et al.
Publicado: (2022)

Quantitative Modeling of GRK-Mediated β2AR Regulation
por: Vayttaden, Sharat J., et al.
Publicado: (2010)

The IgG3 subclass of β1-adrenergic receptor autoantibodies is an endogenous biaser of β1AR signaling
por: Mohan, Maradumane L., et al.
Publicado: (2021)

Signal profiling of the β(1)AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β(1)AR and β(2)AR
por: Lukasheva, Viktoriya, et al.
Publicado: (2020)

Roles of GRK and PDE4 Activities in the Regulation of β(2) Adrenergic Signaling
por: Xin, Wenkuan, et al.
Publicado: (2008)

Computational design and characterization of nanobody-derived peptides that stabilize the active conformation of the β(2)-adrenergic receptor (β(2)-AR)
por: Sencanski, Milan, et al.
Publicado: (2019)

Analysis of β(2)AR-G(s) and β(2)AR-G(i) complex formation by NMR spectroscopy
por: Ma, Xiuyan, et al.
Publicado: (2020)

Enhanced β(2)-adrenergic receptor (β(2)AR) signaling by adeno-associated viral (AAV)-mediated gene transfer
por: Jones, Stacie M, et al.
Publicado: (2003)

β2AR Antagonists and β2AR Gene Deletion Both Promote Skin Wound Repair Processes
por: Pullar, Christine E, et al.
Publicado: (2012)

β(1)-Adrenoceptor Autoantibodies from DCM Patients Enhance the Proliferation of T Lymphocytes through the β(1)-AR/cAMP/PKA and p38 MAPK Pathways
por: Du, Yunhui, et al.
Publicado: (2012)

The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist
por: Erickson, Catherine E., et al.
Publicado: (2013)

GRK2 blockade with βARKct is essential for cardiac β(2)-adrenergic receptor signaling towards increased contractility
por: Salazar, Norma C, et al.
Publicado: (2013)

Macrophage polarization is involved in liver fibrosis induced by β (1)-adrenoceptor autoantibody : β (1)-Adrenoceptor autoantibody and liver fibrosis
por: Wu, Ye, et al.
Publicado: (2022)

Norepinephrine Inhibits Th17 Cells via β2-Adrenergic Receptor (β2-AR) Signaling in a Mouse Model of Rheumatoid Arthritis
por: Liu, Yan, et al.
Publicado: (2018)

The Application of Dynamic Models to the Exploration of β(1)-AR Overactivation as a Cause of Heart Failure
por: Wang, Xiaoyun, et al.
Publicado: (2018)

Decreased Autophagy in Rat Heart Induced by Anti-β1-Adrenergic Receptor Autoantibodies Contributes to the Decline in Mitochondrial Membrane Potential
por: Wang, Li, et al.
Publicado: (2013)

Targeting cardiac β-adrenergic signaling via GRK2 inhibition for heart failure therapy
por: Cannavo, Alessandro, et al.
Publicado: (2013)

Impact of human autoantibodies on β(1)-adrenergic receptor conformation, activity, and internalization
por: Bornholz, Beatrice, et al.
Publicado: (2013)

Structural insights into binding specificity, efficacy and bias of a β(2)AR partial agonist
por: Masureel, Matthieu, et al.
Publicado: (2018)

β(2)ARs: double edge sword in heart function
por: Beasley, Heather K., et al.
Publicado: (2023)

Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression
por: Byun, Seongjun, et al.
Publicado: (2022)

Modulation of CXCR4-Mediated Gi1 Activation by EGF Receptor and GRK2
por: Neves, Maria, et al.
Publicado: (2020)

Single-molecule analysis of ligand efficacy in β(2)AR-G protein activation
por: Gregorio, G. Glenn, et al.
Publicado: (2017)

Myocardial GRK2 Reduces Fatty Acid Metabolism and β-Adrenergic Receptor-Mediated Mitochondrial Responses
por: Zhai, Ruxu, et al.
Publicado: (2022)

Stromal TGF-β signaling induces AR activation in prostate cancer
por: Yang, Feng, et al.
Publicado: (2014)

β(2)-Adrenergic receptor (β(2)-AR) agonist formoterol suppresses differentiation of L6 myogenic cells by blocking PI3K–AKT pathway
por: Kim, So-Hyeon, et al.
Publicado: (2019)

Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor
por: Burghi, Valeria, et al.
Publicado: (2023)

Autoantibodies Activating the β2-Adrenergic Receptor Characterize Patients With Primary and Secondary Glaucoma
por: Hohberger, Bettina, et al.
Publicado: (2019)

Levels in 45K and 46K excited by the β decay of 45Ar and 46Ar
por: Huck, A, et al.
Publicado: (1980)

β-blockers Reverse Agonist-Induced β(2)-AR Downregulation Regardless of Their Signaling Profile
por: Maccari, Sonia, et al.
Publicado: (2020)

Release of Interferon-β (IFN-β) from Probiotic Limosilactobacillus reuteri-IFN-β (LR-IFN-β) Mitigates Gastrointestinal Acute Radiation Syndrome (GI-ARS) following Whole Abdominal Irradiation
por: Hamade, Diala F., et al.
Publicado: (2023)

Proliferation in cardiac fibroblasts induced by β(1)-adrenoceptor autoantibody and the underlying mechanisms
por: Lv, Tingting, et al.
Publicado: (2016)

β-blockers augment L-type Ca(2+) channel activity by targeting spatially restricted β(2)AR signaling in neurons
por: Shen, Ao, et al.
Publicado: (2019)

Decreased autophagy induced by β(1)-adrenoceptor autoantibodies contributes to cardiomyocyte apoptosis
por: Wang, Li, et al.
Publicado: (2018)

Broad-Scale Phosphoprotein Profiling of Beta Adrenergic Receptor (β-AR) Signaling Reveals Novel Phosphorylation and Dephosphorylation Events
por: Chruscinski, Andrzej J., et al.
Publicado: (2013)

Ubiquitination of GRK2 Is Required for the β-Arrestin-Biased Signaling Pathway of Dopamine D2 Receptors to Activate ERK Kinases
por: Liu, Haiping, et al.
Publicado: (2023)

β2‐AR activation promotes cleavage and nuclear translocation of Her2 and metastatic potential of cancer cells
por: Liu, Dan, et al.
Publicado: (2020)

Microtubule-Mediated Regulation of β(2)AR Translation and Function in Failing Hearts
por: Kwan, Zoe, et al.
Publicado: (2023)

C3aR and C5aR1 act as key regulators of human and mouse β-cell function
por: Atanes, Patricio, et al.
Publicado: (2017)

Novel AR/AR-V7 and Mnk1/2 Degrader, VNPP433-3β: Molecular Mechanisms of Action and Efficacy in AR-Overexpressing Castration Resistant Prostate Cancer In Vitro and In Vivo Models
por: Thomas, Elizabeth, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_opqjbsn75ji1r5gdkn6q9onu7j