Stiffer Spleen Predicts Higher Bone Marrow Fibrosis and Higher JAK2 Allele Burden in Patients With Myeloproliferative Neoplasms

A total of 63 myeloproliferative neoplasms [MPN; 9 polycythemia vera (PV), 32 essential thrombocythemia (ET), and 22 myelofibrosis (MF)] underwent spleen stiffness (SS) measurement by vibration-controlled transient elastography equipped with a novel spleen-dedicated module. Higher SS values signific...

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Detalles Bibliográficos
Autores principales: Moia, Riccardo, Cittone, Micol Giulia, Boggione, Paola, Manfredi, Giulia Francesca, Favini, Chiara, Awikeh, Bassel, Pedrinelli, Anita Rebecca, Mahmoud, Abdurraouf Mokhtar, Nicolosi, Maura, Bellan, Mattia, Sainaghi, Pier Paolo, Pirisi, Mario, Gaidano, Gianluca, Patriarca, Andrea, Rigamonti, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576346/
https://www.ncbi.nlm.nih.gov/pubmed/34765563
http://dx.doi.org/10.3389/fonc.2021.777730
Descripción
Sumario:A total of 63 myeloproliferative neoplasms [MPN; 9 polycythemia vera (PV), 32 essential thrombocythemia (ET), and 22 myelofibrosis (MF)] underwent spleen stiffness (SS) measurement by vibration-controlled transient elastography equipped with a novel spleen-dedicated module. Higher SS values significantly correlated with grade 2-3 bone marrow (BM) fibrosis (p=0.035), with hemoglobin level <10 g/dl (p=0.014) and with white blood cells ≥10,000/μl (p=0.008). Median SS was significantly higher in MF patients compared to ET and PV (p=0.015). SS also correlated with higher JAK2 variant allele frequency (p=0.02). This study identifies SS as a potential noninvasive tool that reflects BM fibrosis and the mutational burden in MPN.

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