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Stiffer Spleen Predicts Higher Bone Marrow Fibrosis and Higher JAK2 Allele Burden in Patients With Myeloproliferative Neoplasms
A total of 63 myeloproliferative neoplasms [MPN; 9 polycythemia vera (PV), 32 essential thrombocythemia (ET), and 22 myelofibrosis (MF)] underwent spleen stiffness (SS) measurement by vibration-controlled transient elastography equipped with a novel spleen-dedicated module. Higher SS values signific...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576346/ https://www.ncbi.nlm.nih.gov/pubmed/34765563 http://dx.doi.org/10.3389/fonc.2021.777730 |
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| author | Moia, Riccardo Cittone, Micol Giulia Boggione, Paola Manfredi, Giulia Francesca Favini, Chiara Awikeh, Bassel Pedrinelli, Anita Rebecca Mahmoud, Abdurraouf Mokhtar Nicolosi, Maura Bellan, Mattia Sainaghi, Pier Paolo Pirisi, Mario Gaidano, Gianluca Patriarca, Andrea Rigamonti, Cristina |
| author_facet | Moia, Riccardo Cittone, Micol Giulia Boggione, Paola Manfredi, Giulia Francesca Favini, Chiara Awikeh, Bassel Pedrinelli, Anita Rebecca Mahmoud, Abdurraouf Mokhtar Nicolosi, Maura Bellan, Mattia Sainaghi, Pier Paolo Pirisi, Mario Gaidano, Gianluca Patriarca, Andrea Rigamonti, Cristina |
| author_sort | Moia, Riccardo |
| collection | PubMed |
| description | A total of 63 myeloproliferative neoplasms [MPN; 9 polycythemia vera (PV), 32 essential thrombocythemia (ET), and 22 myelofibrosis (MF)] underwent spleen stiffness (SS) measurement by vibration-controlled transient elastography equipped with a novel spleen-dedicated module. Higher SS values significantly correlated with grade 2-3 bone marrow (BM) fibrosis (p=0.035), with hemoglobin level <10 g/dl (p=0.014) and with white blood cells ≥10,000/μl (p=0.008). Median SS was significantly higher in MF patients compared to ET and PV (p=0.015). SS also correlated with higher JAK2 variant allele frequency (p=0.02). This study identifies SS as a potential noninvasive tool that reflects BM fibrosis and the mutational burden in MPN. |
| format | Online Article Text |
| id | pubmed-8576346 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Frontiers Media S.A. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-85763462021-11-10 Stiffer Spleen Predicts Higher Bone Marrow Fibrosis and Higher JAK2 Allele Burden in Patients With Myeloproliferative Neoplasms Moia, Riccardo Cittone, Micol Giulia Boggione, Paola Manfredi, Giulia Francesca Favini, Chiara Awikeh, Bassel Pedrinelli, Anita Rebecca Mahmoud, Abdurraouf Mokhtar Nicolosi, Maura Bellan, Mattia Sainaghi, Pier Paolo Pirisi, Mario Gaidano, Gianluca Patriarca, Andrea Rigamonti, Cristina Front Oncol Oncology A total of 63 myeloproliferative neoplasms [MPN; 9 polycythemia vera (PV), 32 essential thrombocythemia (ET), and 22 myelofibrosis (MF)] underwent spleen stiffness (SS) measurement by vibration-controlled transient elastography equipped with a novel spleen-dedicated module. Higher SS values significantly correlated with grade 2-3 bone marrow (BM) fibrosis (p=0.035), with hemoglobin level <10 g/dl (p=0.014) and with white blood cells ≥10,000/μl (p=0.008). Median SS was significantly higher in MF patients compared to ET and PV (p=0.015). SS also correlated with higher JAK2 variant allele frequency (p=0.02). This study identifies SS as a potential noninvasive tool that reflects BM fibrosis and the mutational burden in MPN. Frontiers Media S.A. 2021-10-26 /pmc/articles/PMC8576346/ /pubmed/34765563 http://dx.doi.org/10.3389/fonc.2021.777730 Text en Copyright © 2021 Moia, Cittone, Boggione, Manfredi, Favini, Awikeh, Pedrinelli, Mahmoud, Nicolosi, Bellan, Sainaghi, Pirisi, Gaidano, Patriarca and Rigamonti https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| spellingShingle | Oncology Moia, Riccardo Cittone, Micol Giulia Boggione, Paola Manfredi, Giulia Francesca Favini, Chiara Awikeh, Bassel Pedrinelli, Anita Rebecca Mahmoud, Abdurraouf Mokhtar Nicolosi, Maura Bellan, Mattia Sainaghi, Pier Paolo Pirisi, Mario Gaidano, Gianluca Patriarca, Andrea Rigamonti, Cristina Stiffer Spleen Predicts Higher Bone Marrow Fibrosis and Higher JAK2 Allele Burden in Patients With Myeloproliferative Neoplasms |
| title | Stiffer Spleen Predicts Higher Bone Marrow Fibrosis and Higher JAK2 Allele Burden in Patients With Myeloproliferative Neoplasms |
| title_full | Stiffer Spleen Predicts Higher Bone Marrow Fibrosis and Higher JAK2 Allele Burden in Patients With Myeloproliferative Neoplasms |
| title_fullStr | Stiffer Spleen Predicts Higher Bone Marrow Fibrosis and Higher JAK2 Allele Burden in Patients With Myeloproliferative Neoplasms |
| title_full_unstemmed | Stiffer Spleen Predicts Higher Bone Marrow Fibrosis and Higher JAK2 Allele Burden in Patients With Myeloproliferative Neoplasms |
| title_short | Stiffer Spleen Predicts Higher Bone Marrow Fibrosis and Higher JAK2 Allele Burden in Patients With Myeloproliferative Neoplasms |
| title_sort | stiffer spleen predicts higher bone marrow fibrosis and higher jak2 allele burden in patients with myeloproliferative neoplasms |
| topic | Oncology |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576346/ https://www.ncbi.nlm.nih.gov/pubmed/34765563 http://dx.doi.org/10.3389/fonc.2021.777730 |
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