Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages

Obesity-induced white adipose tissue (WAT) hypertrophy is associated with elevated adipose tissue macrophage (ATM) content. Overexpression of the triggering receptor expressed on myeloid cells 2 (TREM2) reportedly increases adiposity, worsening health. Paradoxically, using insulin resistance, elevat...

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Detalles Bibliográficos
Autores principales: Sharif, Omar, Brunner, Julia Stefanie, Korosec, Ana, Martins, Rui, Jais, Alexander, Snijder, Berend, Vogel, Andrea, Caldera, Michael, Hladik, Anastasiya, Lakovits, Karin, Saluzzo, Simona, Boehm, Benedikta, Gorki, Anna-Dorothea, Mesteri, Ildiko, Lindroos-Christensen, Josefine, Tillmann, Katharina, Stoiber, Dagmar, Menche, Jörg, Schabbauer, Gernot, Bilban, Martin, Superti-Furga, Giulio, Esterbauer, Harald, Knapp, Sylvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2021
Materias:
Obesity Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576425/
https://www.ncbi.nlm.nih.gov/pubmed/33627323
http://dx.doi.org/10.2337/db20-0572

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