Adipocyte-Specific Deletion of Lamin A/C Largely Models Human Familial Partial Lipodystrophy Type 2

Mechanisms by which autosomal recessive mutations in Lmna cause familial partial lipodystrophy type 2 (FPLD2) are poorly understood. To investigate the function of lamin A/C in adipose tissue, we created mice with an adipocyte-specific loss of Lmna (Lmna(ADKO)). Although Lmna(ADKO) mice develop and...

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Detalles Bibliográficos
Autores principales: Corsa, Callie A.S., Walsh, Carolyn M., Bagchi, Devika P., Foss Freitas, Maria C., Li, Ziru, Hardij, Julie, Granger, Katrina, Mori, Hiroyuki, Schill, Rebecca L., Lewis, Kenneth T., Maung, Jessica N., Azaria, Ruth D., Rothberg, Amy E., Oral, Elif A., MacDougald, Ormond A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2021
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576431/
https://www.ncbi.nlm.nih.gov/pubmed/34088712
http://dx.doi.org/10.2337/db20-1001

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