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Pharmacological Activation Of Aldehyde Dehydrogenase 2 Protects Against Heatstroke-Induced Acute Lung Injury by Modulating Oxidative Stress and Endothelial Dysfunction

Heatstroke (HS) can cause acute lung injury (ALI). Heat stress induces inflammation and apoptosis via reactive oxygen species (ROS) and endogenous reactive aldehydes. Endothelial dysfunction also plays a crucial role in HS-induced ALI. Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme that...

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Detalles Bibliográficos
Autores principales:	Tsai, Hsiao-Ya, Hsu, Yu-Juei, Lu, Cheng-Yo, Tsai, Min-Chien, Hung, Wan-Chu, Chen, Po-Chuan, Wang, Jen-Chun, Hsu, Lung-An, Yeh, Yung-Hsin, Chu, Pauling, Tsai, Shih-Hung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576434/ https://www.ncbi.nlm.nih.gov/pubmed/34764958 http://dx.doi.org/10.3389/fimmu.2021.740562

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