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Lineage Divergence and Vector-Specific Adaptation Have Driven Chikungunya Virus onto Multiple Adaptive Landscapes

Previous studies have shown that the adaptation of Indian Ocean lineage (IOL) chikungunya virus (CHIKV) strains for Aedes albopictus transmission was mediated by an E1-A226V substitution, followed by either a single substitution in E2 or synergistic substitutions in the E2 and E3 envelope glycoprote...

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Detalles Bibliográficos
Autores principales: Chen, Rubing, Plante, Jessica A., Plante, Kenneth S., Yun, Ruimei, Shinde, Divya, Liu, Jianying, Haller, Sherry, Mukhopadhyay, Suchetana, Weaver, Scott C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576524/
https://www.ncbi.nlm.nih.gov/pubmed/34749526
http://dx.doi.org/10.1128/mBio.02738-21