Restraint of Fumarate Accrual by HIF-1α Preserves miR-27a-Mediated Limitation of Interleukin 10 during Infection of Macrophages by Histoplasma capsulatum

Hypoxia-inducible factor 1α (HIF-1α) regulates the immunometabolic phenotype of macrophages, including the orchestration of inflammatory and antimicrobial processes. Macrophages deficient in HIF-1α produce excessive quantities of the anti-inflammatory cytokine interleukin 10 (IL-10) during infection...

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Detalles Bibliográficos
Autores principales: Evans, Heather M., Schultz, Destiny F., Boiman, Adam J., McKell, Melanie C., Qualls, Joseph E., Deepe, George S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576535/
https://www.ncbi.nlm.nih.gov/pubmed/34749531
http://dx.doi.org/10.1128/mBio.02710-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576535/
https://www.ncbi.nlm.nih.gov/pubmed/34749531
http://dx.doi.org/10.1128/mBio.02710-21

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