Cargando…
Development and Validation of a Radiomics Model Based on (18)F-FDG PET of Primary Gastric Cancer for Predicting Peritoneal Metastasis
OBJECTIVES: The aim of this study was to develop a preoperative positron emission tomography (PET)-based radiomics model for predicting peritoneal metastasis (PM) of gastric cancer (GC). METHODS: In this study, a total of 355 patients (109PM+, 246PM-) who underwent preoperative fluorine-18-fludeoxyg...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576566/ https://www.ncbi.nlm.nih.gov/pubmed/34765549 http://dx.doi.org/10.3389/fonc.2021.740111 |
_version_ | 1784595903178342400 |
---|---|
author | Xue, Beihui Jiang, Jia Chen, Lei Wu, Sunjie Zheng, Xuan Zheng, Xiangwu Tang, Kun |
author_facet | Xue, Beihui Jiang, Jia Chen, Lei Wu, Sunjie Zheng, Xuan Zheng, Xiangwu Tang, Kun |
author_sort | Xue, Beihui |
collection | PubMed |
description | OBJECTIVES: The aim of this study was to develop a preoperative positron emission tomography (PET)-based radiomics model for predicting peritoneal metastasis (PM) of gastric cancer (GC). METHODS: In this study, a total of 355 patients (109PM+, 246PM-) who underwent preoperative fluorine-18-fludeoxyglucose ((18)F-FDG) PET images were retrospectively analyzed. According to a 7:3 ratio, patients were randomly divided into a training set and a validation set. Radiomics features and metabolic parameters data were extracted from PET images. The radiomics features were selected by logistic regression after using maximum relevance and minimum redundancy (mRMR) and the least shrinkage and selection operator (LASSO) method. The radiomics models were based on the rest of these features. The performance of the models was determined by their discrimination, calibration, and clinical usefulness in the training and validation sets. RESULTS: After dimensionality reduction, 12 radiomics feature parameters were obtained to construct radiomics signatures. According to the results of the multivariate logistic regression analysis, only carbohydrate antigen 125 (CA125), maximum standardized uptake value (SUVmax), and the radiomics signature showed statistically significant differences between patients (P<0.05). A radiomics model was developed based on the logistic analyses with an AUC of 0.86 in the training cohort and 0.87 in the validation cohort. The clinical prediction model based on CA125 and SUVmax was 0.76 in the training set and 0.69 in the validation set. The comprehensive model, which contained a rad-score and the clinical factor (CA125) as well as the metabolic parameter (SUVmax), showed promising performance with an AUC of 0.90 in the training cohort and 0.88 in the validation cohort, respectively. The calibration curve showed the actual rate of the nomogram-predicted probability of peritoneal metastasis. Decision curve analysis (DCA) also demonstrated the good clinical utility of the radiomics nomogram. CONCLUSIONS: The comprehensive model based on the rad-score and other factors (SUVmax, CA125) can provide a novel tool for predicting peritoneal metastasis of gastric cancer patients preoperatively. |
format | Online Article Text |
id | pubmed-8576566 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85765662021-11-10 Development and Validation of a Radiomics Model Based on (18)F-FDG PET of Primary Gastric Cancer for Predicting Peritoneal Metastasis Xue, Beihui Jiang, Jia Chen, Lei Wu, Sunjie Zheng, Xuan Zheng, Xiangwu Tang, Kun Front Oncol Oncology OBJECTIVES: The aim of this study was to develop a preoperative positron emission tomography (PET)-based radiomics model for predicting peritoneal metastasis (PM) of gastric cancer (GC). METHODS: In this study, a total of 355 patients (109PM+, 246PM-) who underwent preoperative fluorine-18-fludeoxyglucose ((18)F-FDG) PET images were retrospectively analyzed. According to a 7:3 ratio, patients were randomly divided into a training set and a validation set. Radiomics features and metabolic parameters data were extracted from PET images. The radiomics features were selected by logistic regression after using maximum relevance and minimum redundancy (mRMR) and the least shrinkage and selection operator (LASSO) method. The radiomics models were based on the rest of these features. The performance of the models was determined by their discrimination, calibration, and clinical usefulness in the training and validation sets. RESULTS: After dimensionality reduction, 12 radiomics feature parameters were obtained to construct radiomics signatures. According to the results of the multivariate logistic regression analysis, only carbohydrate antigen 125 (CA125), maximum standardized uptake value (SUVmax), and the radiomics signature showed statistically significant differences between patients (P<0.05). A radiomics model was developed based on the logistic analyses with an AUC of 0.86 in the training cohort and 0.87 in the validation cohort. The clinical prediction model based on CA125 and SUVmax was 0.76 in the training set and 0.69 in the validation set. The comprehensive model, which contained a rad-score and the clinical factor (CA125) as well as the metabolic parameter (SUVmax), showed promising performance with an AUC of 0.90 in the training cohort and 0.88 in the validation cohort, respectively. The calibration curve showed the actual rate of the nomogram-predicted probability of peritoneal metastasis. Decision curve analysis (DCA) also demonstrated the good clinical utility of the radiomics nomogram. CONCLUSIONS: The comprehensive model based on the rad-score and other factors (SUVmax, CA125) can provide a novel tool for predicting peritoneal metastasis of gastric cancer patients preoperatively. Frontiers Media S.A. 2021-10-26 /pmc/articles/PMC8576566/ /pubmed/34765549 http://dx.doi.org/10.3389/fonc.2021.740111 Text en Copyright © 2021 Xue, Jiang, Chen, Wu, Zheng, Zheng and Tang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Xue, Beihui Jiang, Jia Chen, Lei Wu, Sunjie Zheng, Xuan Zheng, Xiangwu Tang, Kun Development and Validation of a Radiomics Model Based on (18)F-FDG PET of Primary Gastric Cancer for Predicting Peritoneal Metastasis |
title | Development and Validation of a Radiomics Model Based on (18)F-FDG PET of Primary Gastric Cancer for Predicting Peritoneal Metastasis |
title_full | Development and Validation of a Radiomics Model Based on (18)F-FDG PET of Primary Gastric Cancer for Predicting Peritoneal Metastasis |
title_fullStr | Development and Validation of a Radiomics Model Based on (18)F-FDG PET of Primary Gastric Cancer for Predicting Peritoneal Metastasis |
title_full_unstemmed | Development and Validation of a Radiomics Model Based on (18)F-FDG PET of Primary Gastric Cancer for Predicting Peritoneal Metastasis |
title_short | Development and Validation of a Radiomics Model Based on (18)F-FDG PET of Primary Gastric Cancer for Predicting Peritoneal Metastasis |
title_sort | development and validation of a radiomics model based on (18)f-fdg pet of primary gastric cancer for predicting peritoneal metastasis |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576566/ https://www.ncbi.nlm.nih.gov/pubmed/34765549 http://dx.doi.org/10.3389/fonc.2021.740111 |
work_keys_str_mv | AT xuebeihui developmentandvalidationofaradiomicsmodelbasedon18ffdgpetofprimarygastriccancerforpredictingperitonealmetastasis AT jiangjia developmentandvalidationofaradiomicsmodelbasedon18ffdgpetofprimarygastriccancerforpredictingperitonealmetastasis AT chenlei developmentandvalidationofaradiomicsmodelbasedon18ffdgpetofprimarygastriccancerforpredictingperitonealmetastasis AT wusunjie developmentandvalidationofaradiomicsmodelbasedon18ffdgpetofprimarygastriccancerforpredictingperitonealmetastasis AT zhengxuan developmentandvalidationofaradiomicsmodelbasedon18ffdgpetofprimarygastriccancerforpredictingperitonealmetastasis AT zhengxiangwu developmentandvalidationofaradiomicsmodelbasedon18ffdgpetofprimarygastriccancerforpredictingperitonealmetastasis AT tangkun developmentandvalidationofaradiomicsmodelbasedon18ffdgpetofprimarygastriccancerforpredictingperitonealmetastasis |