Cargando…

Shikonin regulates autophagy via the AMPK/mTOR pathway and reduces apoptosis of human umbilical cord mesenchymal stem cells to improve survival in tissues surrounding brain contusion

Shikonin has been reported to regulate autophagy via the AMP-activated protein kinase (AMPK)/mTOR signalling pathway and decrease apoptosis in transplanted human umbilical cord mesenchymal stem cells (HUMSCs). In the present study, HUMSCs were exposed to oxygen glucose deprivation (OGD) in vitro for...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Xiaohong, Huang, Lijie, Wu, Ke, Sun, Zhezhe, Wang, Kankai, Ru, Junnan, Zhuge, Qichuan, Ruan, Linhui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576632/ https://www.ncbi.nlm.nih.gov/pubmed/34765016 http://dx.doi.org/10.3892/etm.2021.10910

Ejemplares similares

VX‐765 enhances autophagy of human umbilical cord mesenchymal stem cells against stroke‐induced apoptosis and inflammatory responses via AMPK/mTOR signaling pathway
por: Sun, Zhezhe, et al.
Publicado: (2020)

Ablation of GSDMD Improves Outcome of Ischemic Stroke Through Blocking Canonical and Non-canonical Inflammasomes Dependent Pyroptosis in Microglia
por: Wang, Kankai, et al.
Publicado: (2020)

VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-κB Pathways to Improve Functional Outcomes in TBI Mice
por: Sun, Zhezhe, et al.
Publicado: (2020)

Melatonin Enhances the Therapeutic Effect of Plasma Exosomes Against Cerebral Ischemia-Induced Pyroptosis Through the TLR4/NF-κB Pathway
por: Wang, Kankai, et al.
Publicado: (2020)

Neuregulin-4 attenuates diabetic cardiomyopathy by regulating autophagy via the AMPK/mTOR signalling pathway
por: Wang, Hongchao, et al.
Publicado: (2022)

Exosomes derived from umbilical cord mesenchymal stem cells alleviate viral myocarditis through activating AMPK/mTOR‐mediated autophagy flux pathway
por: Gu, Xiaohong, et al.
Publicado: (2020)

Ozone induces autophagy in rat chondrocytes stimulated with IL-1β through the AMPK/mTOR signaling pathway
por: Zhao, Xu, et al.
Publicado: (2018)

ANXA1 as a Prognostic and Immune Microenvironmental Marker for Gliomas Based on Transcriptomic Analysis and Experimental Validation
por: Lin, Zhongxiao, et al.
Publicado: (2021)

AMPK–mTOR Signaling and Cellular Adaptations in Hypoxia
por: Chun, Yoomi, et al.
Publicado: (2021)

Preclinical Studies and Translational Applications of Intracerebral Hemorrhage
por: Siaw-Debrah, Felix, et al.
Publicado: (2017)

Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway
por: Wang, Jiwei, et al.
Publicado: (2016)

Phellodendrine promotes autophagy by regulating the AMPK/mTOR pathway and treats ulcerative colitis
por: Su, Shuai, et al.
Publicado: (2021)

Dapagliflozin Alleviates Hepatic Steatosis by Restoring Autophagy via the AMPK-mTOR Pathway
por: Li, Liuran, et al.
Publicado: (2021)

Metformin Attenuates Silica-Induced Pulmonary Fibrosis by Activating Autophagy via the AMPK-mTOR Signaling Pathway
por: Li, Shu-xian, et al.
Publicado: (2021)

Central Exercise Action Increases the AMPK and mTOR Response to Leptin
por: Ropelle, Eduardo R., et al.
Publicado: (2008)

TFEC contributes to cardiac hypertrophy by inhibiting AMPK/mTOR signaling
por: Zhao, Ting, et al.
Publicado: (2021)

A Reliable Nonhuman Primate Model of Ischemic Stroke with Reproducible Infarct Size and Long-term Sensorimotor Deficits
por: Lin, Xiao, et al.
Publicado: (2023)

Activating autophagy and ferroptosis of 3‑Chloropropane‑1,2‑diol induces injury of human umbilical vein endothelial cells via AMPK/mTOR/ULK1
por: Yi, Xin, et al.
Publicado: (2023)

Rhein Inhibits Autophagy in Rat Renal Tubular Cells by Regulation of AMPK/mTOR Signaling
por: Tu, Yue, et al.
Publicado: (2017)

Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy
por: Ganesan, Raja, et al.
Publicado: (2017)

Trifolirhizin induces autophagy-dependent apoptosis in colon cancer via AMPK/mTOR signaling
por: Sun, Dongdong, et al.
Publicado: (2020)

Trimetazidine ameliorates sunitinib-induced cardiotoxicity in mice via the AMPK/mTOR/autophagy pathway
por: Yang, Yi, et al.
Publicado: (2019)

AMPK/mTOR Signaling in Autophagy Regulation During Cisplatin-Induced Acute Kidney Injury
por: Wang, Ying, et al.
Publicado: (2020)

Role of Autophagy Mediated by AMPK/DDiT4/mTOR Axis in HT22 Cells Under Oxygen and Glucose Deprivation/Reoxygenation
por: Zhang, Yi, et al.
Publicado: (2023)

Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway
por: Zheng, Xiangjin, et al.
Publicado: (2021)

Duck Tembusu virus induces incomplete autophagy via the ERK/mTOR and AMPK/mTOR signalling pathways to promote viral replication in neuronal cells
por: Wang, Qing, et al.
Publicado: (2023)

Inhibition of mammalian target of rapamycin improves neurobehavioral deficit and modulates immune response after intracerebral hemorrhage in rat
por: Lu, Qin, et al.
Publicado: (2014)

β-hydroxyisovaleryl-shikonin induces human cervical cancer cell apoptosis via PI3K/AKT/mTOR signaling
por: LU, DAN, et al.
Publicado: (2015)

β-Hydroxyisovaleryl-shikonin induces human cervical cancer cell apoptosis via PI3K/AKT/mTOR signaling
por: Lu, Dan, et al.
Publicado: (2021)

Feeding Uninvited Guests: mTOR and AMPK Set the Table for Intracellular Pathogens
por: Brunton, Jason, et al.
Publicado: (2013)

Retraction: Central Exercise Action Increases the AMPK and mTOR Response to Leptin
Publicado: (2018)

Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK
por: Su, Yuan, et al.
Publicado: (2019)

Glucose activates the primordial follicle through the AMPK/mTOR signaling pathway
por: Xu, Shengyu, et al.
Publicado: (2020)

How does mTOR sense glucose starvation? AMPK is the usual suspect
por: Leprivier, Gabriel, et al.
Publicado: (2020)

Folliculin: A Regulator of Transcription Through AMPK and mTOR Signaling Pathways
por: Ramirez Reyes, Josué M. J., et al.
Publicado: (2021)

Editorial: AMPK and mTOR Beyond Signaling: Emerging Roles in Transcriptional Regulation
por: Audet-Walsh, Étienne, et al.
Publicado: (2021)

Computational modeling of AMPK and mTOR crosstalk in glutamatergic synapse calcium signaling
por: Leung, A., et al.
Publicado: (2023)

Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight
por: Rigacci, Stefania, et al.
Publicado: (2015)

Autophagy facilitates lung adenocarcinoma resistance to cisplatin treatment by activation of AMPK/mTOR signaling pathway
por: Wu, Tao, et al.
Publicado: (2015)

CSC-3436 switched tamoxifen-induced autophagy to apoptosis through the inhibition of AMPK/mTOR pathway
por: Wu, Sheng-Tang, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_o88kf9rv4pa4c1ubkjkik5svv9