Polyprenylated Acylphloroglucinols With Different Carbon Skeletons From the Fruits of Garcinia multiflora

Eleven new polycyclic polyprenylated acylphloroglucinols (PPAPs, 1–11) and three new monocyclic polyprenylated acylphloroglucinols (MPAPs, 12–14), together with ten known analogues were isolated from the fruits of Garcinia multiflora. These PPAPs belong to three types including the bicyclic polypren...

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Autores principales: Teng, Haida, Li, Qingqing, Ma, Ziyu, Li, Xueni, Xie, Wenli, Chen, Yu, Yang, Guangzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576638/
https://www.ncbi.nlm.nih.gov/pubmed/34765586
http://dx.doi.org/10.3389/fchem.2021.756452
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author Teng, Haida
Li, Qingqing
Ma, Ziyu
Li, Xueni
Xie, Wenli
Chen, Yu
Yang, Guangzhong
author_facet Teng, Haida
Li, Qingqing
Ma, Ziyu
Li, Xueni
Xie, Wenli
Chen, Yu
Yang, Guangzhong
author_sort Teng, Haida
collection PubMed
description Eleven new polycyclic polyprenylated acylphloroglucinols (PPAPs, 1–11) and three new monocyclic polyprenylated acylphloroglucinols (MPAPs, 12–14), together with ten known analogues were isolated from the fruits of Garcinia multiflora. These PPAPs belong to three types including the bicyclic polyprenylated acylphloroglucinols (BPAPs), the caged PPAPs, and the complicated PPAPs. Their structures and absolute configurations were determined through HRESIMS, NMR spectroscopy data, electronic circular dichroism (ECD) calculations, and gauge-independent atomic orbital (GIAO) NMR calculations with DP4+ analyses. Moreover, compounds 2 and 7 exhibited moderate cytotoxicity against three human cancer lines (MCF-7, T98, and HepG2) with IC(50) values ranging from 9.81 ± 1.56 to 17.00 ± 2.75 μM.
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spelling pubmed-85766382021-11-10 Polyprenylated Acylphloroglucinols With Different Carbon Skeletons From the Fruits of Garcinia multiflora Teng, Haida Li, Qingqing Ma, Ziyu Li, Xueni Xie, Wenli Chen, Yu Yang, Guangzhong Front Chem Chemistry Eleven new polycyclic polyprenylated acylphloroglucinols (PPAPs, 1–11) and three new monocyclic polyprenylated acylphloroglucinols (MPAPs, 12–14), together with ten known analogues were isolated from the fruits of Garcinia multiflora. These PPAPs belong to three types including the bicyclic polyprenylated acylphloroglucinols (BPAPs), the caged PPAPs, and the complicated PPAPs. Their structures and absolute configurations were determined through HRESIMS, NMR spectroscopy data, electronic circular dichroism (ECD) calculations, and gauge-independent atomic orbital (GIAO) NMR calculations with DP4+ analyses. Moreover, compounds 2 and 7 exhibited moderate cytotoxicity against three human cancer lines (MCF-7, T98, and HepG2) with IC(50) values ranging from 9.81 ± 1.56 to 17.00 ± 2.75 μM. Frontiers Media S.A. 2021-10-26 /pmc/articles/PMC8576638/ /pubmed/34765586 http://dx.doi.org/10.3389/fchem.2021.756452 Text en Copyright © 2021 Teng, Li, Ma, Li, Xie, Chen and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Teng, Haida
Li, Qingqing
Ma, Ziyu
Li, Xueni
Xie, Wenli
Chen, Yu
Yang, Guangzhong
Polyprenylated Acylphloroglucinols With Different Carbon Skeletons From the Fruits of Garcinia multiflora
title Polyprenylated Acylphloroglucinols With Different Carbon Skeletons From the Fruits of Garcinia multiflora
title_full Polyprenylated Acylphloroglucinols With Different Carbon Skeletons From the Fruits of Garcinia multiflora
title_fullStr Polyprenylated Acylphloroglucinols With Different Carbon Skeletons From the Fruits of Garcinia multiflora
title_full_unstemmed Polyprenylated Acylphloroglucinols With Different Carbon Skeletons From the Fruits of Garcinia multiflora
title_short Polyprenylated Acylphloroglucinols With Different Carbon Skeletons From the Fruits of Garcinia multiflora
title_sort polyprenylated acylphloroglucinols with different carbon skeletons from the fruits of garcinia multiflora
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576638/
https://www.ncbi.nlm.nih.gov/pubmed/34765586
http://dx.doi.org/10.3389/fchem.2021.756452
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