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Metformin alleviates bevacizumab-induced vascular endothelial injury by up-regulating GDF15 and activating the PI3K/AKT/FOXO/PPARγ signaling pathway

BACKGROUND: Previous studies have reported that the combination of metformin and bevacizumab exhibit favorable efficacy in the treatment of cancer patients, and metformin possesses effects on relieving vascular injury in multiple diseases. Nonetheless, the effect of metformin in alleviating bevacizu...

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Detalles Bibliográficos
Autores principales:	Chen, Liqiang, Yin, Yajuan, Liu, Gang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576656/ https://www.ncbi.nlm.nih.gov/pubmed/34790753 http://dx.doi.org/10.21037/atm-21-4764

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