Cargando…
Nyctinastic herbs decoction improves para-chlorophenylalanine-induced insomnia by regulating the expression level of neurotransmitters
BACKGROUND: As traditional Chinese medicine (TCM), nyctinastic herbs have been used in treating insomnia in China since ancient times according to its similar circadian rhythm as human beings. However, the pharmacodynamic characteristics and mechanism of these herbs have not been explored in depth....
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576665/ https://www.ncbi.nlm.nih.gov/pubmed/34790730 http://dx.doi.org/10.21037/atm-21-4462 |
_version_ | 1784595922149179392 |
---|---|
author | Yang, Yiwen Wu, You Xu, Peiqin Guo, Fan Guo, Fei Yang, Baican |
author_facet | Yang, Yiwen Wu, You Xu, Peiqin Guo, Fan Guo, Fei Yang, Baican |
author_sort | Yang, Yiwen |
collection | PubMed |
description | BACKGROUND: As traditional Chinese medicine (TCM), nyctinastic herbs have been used in treating insomnia in China since ancient times according to its similar circadian rhythm as human beings. However, the pharmacodynamic characteristics and mechanism of these herbs have not been explored in depth. METHODS: In the study, we chose He Huan Pi (Albizia julibrissin Durazz.), Ye Jiao Teng (Polygonum multiflorum Thunb.), Bai He (Lilium brownie F. E. Brown var. viridulum Baker), and Lianzi (Nelumbo nucifera Gaertn) to form a TCM compound decoction [nyctinastic herb decoction (NHD)] and to investigate its sedative and hypnotic effect on para-chlorophenylalanine (PCPA)-induced insomnia rodents by pentobarbital-induced sleep test (PIST), behavior test [including locomotor activity (LMA), forced swim test (FST), tail suspension test (TST)] and electroencephalograph (EEG). The expression of neurotransmitters were detected to explain the possible mechanism of NHD. RESULTS: NHD was found to have good sedative effects on reducing the moving distance, prolonging sleep time, improving the sleep quality and depression status. NHD attenuated the insomniac effect of PCPA by increasing the level of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA), and reducing the level of dopamine (DA), norepinephrine (NE), acetylcholine (ACh) in the hypothalamus. CONCLUSIONS: The findings of the present study confirmed the sedative and hypnotic effect of NHD, and clarified its possible mechanism from neurotransmitters. |
format | Online Article Text |
id | pubmed-8576665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-85766652021-11-16 Nyctinastic herbs decoction improves para-chlorophenylalanine-induced insomnia by regulating the expression level of neurotransmitters Yang, Yiwen Wu, You Xu, Peiqin Guo, Fan Guo, Fei Yang, Baican Ann Transl Med Original Article BACKGROUND: As traditional Chinese medicine (TCM), nyctinastic herbs have been used in treating insomnia in China since ancient times according to its similar circadian rhythm as human beings. However, the pharmacodynamic characteristics and mechanism of these herbs have not been explored in depth. METHODS: In the study, we chose He Huan Pi (Albizia julibrissin Durazz.), Ye Jiao Teng (Polygonum multiflorum Thunb.), Bai He (Lilium brownie F. E. Brown var. viridulum Baker), and Lianzi (Nelumbo nucifera Gaertn) to form a TCM compound decoction [nyctinastic herb decoction (NHD)] and to investigate its sedative and hypnotic effect on para-chlorophenylalanine (PCPA)-induced insomnia rodents by pentobarbital-induced sleep test (PIST), behavior test [including locomotor activity (LMA), forced swim test (FST), tail suspension test (TST)] and electroencephalograph (EEG). The expression of neurotransmitters were detected to explain the possible mechanism of NHD. RESULTS: NHD was found to have good sedative effects on reducing the moving distance, prolonging sleep time, improving the sleep quality and depression status. NHD attenuated the insomniac effect of PCPA by increasing the level of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA), and reducing the level of dopamine (DA), norepinephrine (NE), acetylcholine (ACh) in the hypothalamus. CONCLUSIONS: The findings of the present study confirmed the sedative and hypnotic effect of NHD, and clarified its possible mechanism from neurotransmitters. AME Publishing Company 2021-10 /pmc/articles/PMC8576665/ /pubmed/34790730 http://dx.doi.org/10.21037/atm-21-4462 Text en 2021 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Original Article Yang, Yiwen Wu, You Xu, Peiqin Guo, Fan Guo, Fei Yang, Baican Nyctinastic herbs decoction improves para-chlorophenylalanine-induced insomnia by regulating the expression level of neurotransmitters |
title | Nyctinastic herbs decoction improves para-chlorophenylalanine-induced insomnia by regulating the expression level of neurotransmitters |
title_full | Nyctinastic herbs decoction improves para-chlorophenylalanine-induced insomnia by regulating the expression level of neurotransmitters |
title_fullStr | Nyctinastic herbs decoction improves para-chlorophenylalanine-induced insomnia by regulating the expression level of neurotransmitters |
title_full_unstemmed | Nyctinastic herbs decoction improves para-chlorophenylalanine-induced insomnia by regulating the expression level of neurotransmitters |
title_short | Nyctinastic herbs decoction improves para-chlorophenylalanine-induced insomnia by regulating the expression level of neurotransmitters |
title_sort | nyctinastic herbs decoction improves para-chlorophenylalanine-induced insomnia by regulating the expression level of neurotransmitters |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576665/ https://www.ncbi.nlm.nih.gov/pubmed/34790730 http://dx.doi.org/10.21037/atm-21-4462 |
work_keys_str_mv | AT yangyiwen nyctinasticherbsdecoctionimprovesparachlorophenylalanineinducedinsomniabyregulatingtheexpressionlevelofneurotransmitters AT wuyou nyctinasticherbsdecoctionimprovesparachlorophenylalanineinducedinsomniabyregulatingtheexpressionlevelofneurotransmitters AT xupeiqin nyctinasticherbsdecoctionimprovesparachlorophenylalanineinducedinsomniabyregulatingtheexpressionlevelofneurotransmitters AT guofan nyctinasticherbsdecoctionimprovesparachlorophenylalanineinducedinsomniabyregulatingtheexpressionlevelofneurotransmitters AT guofei nyctinasticherbsdecoctionimprovesparachlorophenylalanineinducedinsomniabyregulatingtheexpressionlevelofneurotransmitters AT yangbaican nyctinasticherbsdecoctionimprovesparachlorophenylalanineinducedinsomniabyregulatingtheexpressionlevelofneurotransmitters |