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Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase

A hallmark of type 2 diabetes (T2D) is hepatic resistance to insulin’s glucose-lowering effects. The serum- and glucocorticoid-regulated family of protein kinases (SGK) is activated downstream of mechanistic target of rapamycin complex 2 (mTORC2) in response to insulin in parallel to AKT. Surprising...

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Detalles Bibliográficos
Autores principales:	Zhou, Ben, Zhang, Yuyao, Li, Sainan, Wu, Lianfeng, Fejes-Toth, Geza, Naray-Fejes-Toth, Aniko, Soukas, Alexander A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576737/ https://www.ncbi.nlm.nih.gov/pubmed/34610303 http://dx.doi.org/10.1016/j.celrep.2021.109785

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